Detailed information of TA system TA239817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1254569..1255046
• Replicon: chromosome
• Accession: NZ_CP094443
• Organism: Staphylococcus aureus strain N10CSA27

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MTP23_RS06450
• Protein ID: WP_000052076.1
• Coordinates: 1254858..1255046 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MTP23_RS06445
• Protein ID: WP_001059690.1
• Coordinates: 1254569..1254829 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP23_RS06410 (1249962)	1249962..1250678	-	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-
MTP23_RS06415 (1250826)	1250826..1251248	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
MTP23_RS06420 (1251646)	1251646..1252140	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MTP23_RS06425 (1252295)	1252295..1252911	+	617	Protein_1241	LysE/ArgO family amino acid transporter	-
MTP23_RS06430 (1252984)	1252984..1253565	-	582	WP_001140693.1	histidine phosphatase family protein	-
MTP23_RS06435 (1253792)	1253792..1254028	+	237	WP_000349581.1	hypothetical protein	-
MTP23_RS06440 (1254025)	1254025..1254228	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MTP23_RS06445 (1254569)	1254569..1254829	+	261	WP_001059690.1	hypothetical protein	Antitoxin
MTP23_RS06450 (1254858)	1254858..1255046	+	189	WP_000052076.1	hypothetical protein	Toxin
MTP23_RS06455 (1255234)	1255234..1255803	+	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
MTP23_RS06460 (1255891)	1255891..1256175	+	285	WP_001004399.1	hypothetical protein	-
MTP23_RS06465 (1256237)	1256237..1256455	+	219	WP_000005886.1	hypothetical protein	-
MTP23_RS06470 (1256947)	1256947..1257147	-	201	WP_001059082.1	cold-shock protein	-
MTP23_RS06475 (1257504)	1257504..1258190	-	687	WP_000141557.1	thermonuclease family protein	-
MTP23_RS06480 (1258531)	1258531..1259052	-	522	WP_000824482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / seb	1251646..1286480	34834

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T239817 WP_000052076.1 NZ_CP094443:1254858-1255046 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T239817 NZ_LS483342:1806591-1806926 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT239817 WP_001059690.1 NZ_CP094443:1254569-1254829 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT239817 NZ_LS483342:1806314-1806601 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56