Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 506805..507593 | Replicon | chromosome |
| Accession | NZ_CP094443 | ||
| Organism | Staphylococcus aureus strain N10CSA27 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | MTP23_RS02725 | Protein ID | WP_000525004.1 |
| Coordinates | 506805..507266 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MTP23_RS02730 | Protein ID | WP_000333631.1 |
| Coordinates | 507279..507593 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MTP23_RS02700 (501815) | 501815..503842 | + | 2028 | WP_001558502.1 | hypothetical protein | - |
| MTP23_RS02705 (503885) | 503885..505090 | - | 1206 | WP_000264751.1 | site-specific integrase | - |
| MTP23_RS02710 (505216) | 505216..505830 | + | 615 | WP_000191470.1 | hypothetical protein | - |
| MTP23_RS02715 (505827) | 505827..505973 | - | 147 | WP_001795334.1 | hypothetical protein | - |
| MTP23_RS02720 (506203) | 506203..506787 | - | 585 | WP_000825949.1 | hypothetical protein | - |
| MTP23_RS02725 (506805) | 506805..507266 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| MTP23_RS02730 (507279) | 507279..507593 | - | 315 | WP_000333631.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MTP23_RS02735 (507745) | 507745..507975 | + | 231 | WP_001661993.1 | helix-turn-helix transcriptional regulator | - |
| MTP23_RS02740 (507994) | 507994..508770 | + | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| MTP23_RS02745 (508799) | 508799..509044 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MTP23_RS02750 (509013) | 509013..509378 | - | 366 | WP_001128433.1 | hypothetical protein | - |
| MTP23_RS02755 (509433) | 509433..509648 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| MTP23_RS02760 (509675) | 509675..509938 | + | 264 | WP_001124194.1 | helix-turn-helix domain-containing protein | - |
| MTP23_RS02765 (509951) | 509951..510112 | + | 162 | WP_001285948.1 | DUF1270 domain-containing protein | - |
| MTP23_RS02770 (510191) | 510191..510514 | + | 324 | WP_000174999.1 | hypothetical protein | - |
| MTP23_RS02775 (510529) | 510529..510891 | + | 363 | WP_000985972.1 | hypothetical protein | - |
| MTP23_RS02780 (510888) | 510888..512054 | + | 1167 | WP_000762552.1 | DUF2800 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T239812 WP_000525004.1 NZ_CP094443:c507266-506805 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T239812 NZ_LS483334:1597598-1597933 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12062.58 Da Isoelectric Point: 7.1661
>AT239812 WP_000333631.1 NZ_CP094443:c507593-507279 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYANYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYANYIRSKRK
Download Length: 315 bp
>AT239812 NZ_LS483334:1597321-1597608 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|