Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 833721..834246 Replicon chromosome
Accession NC_012917
Organism Pectobacterium carotovorum subsp. carotovorum PC1

Toxin (Protein)


Gene name relE Uniprot ID C6D955
Locus tag PC1_RS03555 Protein ID WP_012773408.1
Coordinates 833721..834005 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C6D956
Locus tag PC1_RS03560 Protein ID WP_005973616.1
Coordinates 833995..834246 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PC1_RS03535 829686..830168 + 483 WP_012773403.1 GNAT family N-acetyltransferase -
PC1_RS03540 830212..830838 - 627 WP_012773404.1 LysE family transporter -
PC1_RS03545 831106..831888 - 783 WP_012773405.1 ABC transporter substrate-binding protein -
PC1_RS03550 832253..832831 - 579 WP_012773406.1 hypothetical protein -
PC1_RS22265 833290..833466 - 177 WP_012773407.1 hypothetical protein -
PC1_RS03555 833721..834005 - 285 WP_012773408.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PC1_RS03560 833995..834246 - 252 WP_005973616.1 prevent-host-death protein Antitoxin
PC1_RS03565 834509..836836 - 2328 WP_012773409.1 toprim domain-containing protein -
PC1_RS03570 836847..837188 - 342 WP_012773410.1 DUF5375 family protein -
PC1_RS21605 837185..837451 - 267 WP_012773411.1 hypothetical protein -
PC1_RS22460 837448..838179 - 732 WP_080516288.1 ash family protein -
PC1_RS03590 838188..838412 - 225 WP_012773413.1 hypothetical protein -
PC1_RS03595 838409..838669 - 261 WP_012773414.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11008.95 Da        Isoelectric Point: 10.1982

>T23981 WP_012773408.1 NC_012917:c834005-833721 [Pectobacterium carotovorum subsp. carotovorum PC1]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEVLRNPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYQAAKDRL

Download         Length: 285 bp

>T23981 NC_012917:c834005-833721 [Pectobacterium carotovorum subsp. carotovorum PC1]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCGCTGAAAGAATTTAAGAAGCTGGGTGCACCCGTGCGGGAGCAGTTCAC
CAAAAAACTGAAAGAGGTTTTACGAAATCCCCACGTTCCCGCCAACCGGCTTCACGGAATGGCTGACTGCTACAAAATCA
AACTTCGTTCCGCTGGCTATCGGTTAGTGTATCAAGTGCTTGAGCATGAGATCGTGGTACTGGTTTTAGCTGTGGGCAAA
CGGGAACGCTCAGAGGTTTATCAAGCAGCTAAAGACCGACTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9079.35 Da        Isoelectric Point: 5.0807

>AT23981 WP_005973616.1 NC_012917:c834246-833995 [Pectobacterium carotovorum subsp. carotovorum PC1]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Download         Length: 252 bp

>AT23981 NC_012917:c834246-833995 [Pectobacterium carotovorum subsp. carotovorum PC1]
ATGTCCGTACAACCTATTCTTGCCAATGCTGCCGTGAGTATTAGCGACTTTAAAAAATCGCCCAATGCCGCGCTGAAAGA
AGCTAACGGCGAGCCTGTAGCCGTGTTAACCAATGGCCGTATCTCTGGCTATTATGTTTCCCCGGAAACATGGGAAGCGC
TGGCCGACTATCAGGAAGATATCGAACTTGCCAAAATTGCCCGTTCCCGGATGAAGGGGAAACGTGTGAAGGTCGATCTG
GATGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C6D955

Antitoxin

Source ID Structure
AlphaFold DB A0A0G4JQP6

References