Detailed information of TA system TA239809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 122666..123442
• Replicon: chromosome
• Accession: NZ_CP094443
• Organism: Staphylococcus aureus strain N10CSA27

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: MTP23_RS00790
• Protein ID: WP_000031108.1
• Coordinates: 123290..123442 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: MTP23_RS00785
• Protein ID: WP_001251224.1
• Coordinates: 122666..123265 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP23_RS00765 (118582)	118582..120039	+	1458	WP_000649908.1	ABC transporter permease subunit	-
MTP23_RS00770 (120032)	120032..120754	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
MTP23_RS00775 (120905)	120905..122032	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
MTP23_RS00780 (122037)	122037..122507	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MTP23_RS00785 (122666)	122666..123265	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
MTP23_RS00790 (123290)	123290..123442	+	153	WP_000031108.1	SAS053 family protein	Toxin
MTP23_RS00795 (123990)	123990..124385	+	396	WP_000901023.1	hypothetical protein	-
MTP23_RS00800 (124581)	124581..125966	+	1386	WP_000116228.1	class II fumarate hydratase	-
MTP23_RS00805 (126419)	126419..127240	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T239809 WP_000031108.1 NZ_CP094443:123290-123442 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T239809 NZ_LS483331:1606325-1606660 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT239809 WP_001251224.1 NZ_CP094443:122666-123265 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT239809 NZ_LS483331:1606048-1606335 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAATAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4