Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 742385..743045 Replicon chromosome
Accession NC_012917
Organism Pectobacterium carotovorum subsp. carotovorum PC1

Toxin (Protein)


Gene name cptA Uniprot ID A0A7W2E4X8
Locus tag PC1_RS03205 Protein ID WP_012773341.1
Coordinates 742632..743045 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C6D8Y5
Locus tag PC1_RS03200 Protein ID WP_012773340.1
Coordinates 742385..742651 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PC1_RS03180 738377..739381 - 1005 WP_012773336.1 LacI family DNA-binding transcriptional regulator -
PC1_RS03185 739425..740033 - 609 WP_012773337.1 HD domain-containing protein -
PC1_RS03190 740446..741093 + 648 WP_012773338.1 hemolysin III family protein -
PC1_RS03195 741148..742149 - 1002 WP_012773339.1 tRNA-modifying protein YgfZ -
PC1_RS03200 742385..742651 + 267 WP_012773340.1 FAD assembly factor SdhE Antitoxin
PC1_RS03205 742632..743045 + 414 WP_012773341.1 protein YgfX Toxin
PC1_RS03210 743115..744050 + 936 WP_012773342.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
PC1_RS03215 744095..744418 - 324 WP_012773343.1 hypothetical protein -
PC1_RS03220 744447..744965 - 519 WP_012773344.1 flavodoxin FldB -
PC1_RS03225 745296..745682 - 387 WP_012773345.1 thioesterase family protein -
PC1_RS03230 745883..747211 - 1329 WP_012773346.1 MHS family MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-132)

Antitoxin

(8-79)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 16302.21 Da        Isoelectric Point: 10.6525

>T23980 WP_012773341.1 NC_012917:742632-743045 [Pectobacterium carotovorum subsp. carotovorum PC1]
VAQWQCDLRVSWRMQLLSLIVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDRQQLWLASDSMGDDEWRHLRQLLLQQKNWAR

Download         Length: 414 bp

>T23980 NC_012917:742632-743045 [Pectobacterium carotovorum subsp. carotovorum PC1]
GTGGCCCAGTGGCAATGTGATCTTCGCGTTTCCTGGCGTATGCAACTGCTTTCATTGATTGTGCATGGCCTATTAGTATT
GCTCATTCTTCTGGCACCGTGGCCGGACGGCTATGCATGGCTGTGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAAAGGAATATCAAATCCCGGCAGGGGGAAATCGTTTTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAGATCGTTAAACGACCGTGGTTGCTGAAAAATGGCGTATTGCTGTCATTGCAGGCAGTGAACGGTAAAGACAG
ACAACAACTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCATCTGCGTCAGCTTCTTTTGCAGCAGAAAA
ACTGGGCGAGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10465.94 Da        Isoelectric Point: 6.2223

>AT23980 WP_012773340.1 NC_012917:742385-742651 [Pectobacterium carotovorum subsp. carotovorum PC1]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLSDSDKRTFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT23980 NC_012917:742385-742651 [Pectobacterium carotovorum subsp. carotovorum PC1]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGGGGTATGCGTGAGTTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTACGACACACTCAGTGACAGCGATAAGCGCACCTTTGTGCGCCTGTTACAAAGCGATGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCGAGCCGAAAGACGGAGAGCTGAAACGCATGATTTCTCTTATTCAAACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7W2E4X8


Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E501

References