Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2583091..2583764 Replicon chromosome
Accession NZ_CP094359
Organism Acidithiobacillus sp. YTS05

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MQE22_RS12825 Protein ID WP_215873656.1
Coordinates 2583342..2583764 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MQE22_RS12820 Protein ID WP_215851307.1
Coordinates 2583091..2583345 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE22_RS12805 (MQE22_12800) 2579108..2581606 + 2499 WP_215873654.1 type IV secretory system conjugative DNA transfer family protein -
MQE22_RS12810 (MQE22_12805) 2581575..2582198 - 624 WP_226838461.1 lytic transglycosylase domain-containing protein -
MQE22_RS12815 (MQE22_12810) 2582195..2582869 - 675 WP_215873655.1 S26 family signal peptidase -
MQE22_RS12820 (MQE22_12815) 2583091..2583345 + 255 WP_215851307.1 plasmid stabilization protein Antitoxin
MQE22_RS12825 (MQE22_12820) 2583342..2583764 + 423 WP_215873656.1 type II toxin-antitoxin system VapC family toxin Toxin
MQE22_RS12830 (MQE22_12825) 2584004..2584279 - 276 WP_215873657.1 hypothetical protein -
MQE22_RS12835 (MQE22_12830) 2584276..2585427 - 1152 WP_215873658.1 hypothetical protein -
MQE22_RS12840 (MQE22_12835) 2585443..2586495 - 1053 WP_215873659.1 hypothetical protein -
MQE22_RS12845 (MQE22_12840) 2586547..2586915 - 369 WP_215873660.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14981.10 Da        Isoelectric Point: 4.6697

>T239780 WP_215873656.1 NZ_CP094359:2583342-2583764 [Acidithiobacillus sp. YTS05]
MIVLDTNVISEAMKAEPNSAVRAWLDEQVAETLYLSSVTLAELLFGIGALPSGRRKDTLSQTLDGLLELFGDRVLAFDTD
AARHYADLAVTARAAGKGFPTPDGYIAAIAKARGFTVATRDVAPFQAAGLNVINPWEAMR

Download         Length: 423 bp

>T239780 NZ_CP094359:2583342-2583764 [Acidithiobacillus sp. YTS05]
ATGATCGTCCTGGATACCAACGTCATTTCCGAGGCGATGAAAGCGGAACCGAATTCCGCCGTGCGGGCGTGGCTGGATGA
GCAGGTTGCCGAAACGCTTTACCTGTCCAGCGTCACGCTTGCCGAGCTGCTGTTCGGCATCGGTGCCCTGCCGTCTGGCC
GGCGCAAGGATACGCTGTCGCAAACGCTGGATGGCCTGCTGGAACTATTCGGGGATCGCGTGCTTGCCTTCGACACCGAC
GCAGCCCGGCACTACGCCGATCTGGCCGTTACCGCCCGTGCTGCCGGCAAGGGCTTCCCTACGCCAGACGGCTACATCGC
CGCCATTGCGAAAGCGCGCGGCTTCACGGTCGCCACGCGCGACGTTGCGCCGTTCCAGGCGGCCGGCCTCAACGTCATCA
ACCCGTGGGAGGCCATGCGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9430.61 Da        Isoelectric Point: 6.2300

>AT239780 WP_215851307.1 NZ_CP094359:2583091-2583345 [Acidithiobacillus sp. YTS05]
MATVTVRNLPDEVHRALRVRAATHGRSTEAEIRDILESTVRPSERLRLGTALAELGRRVGLTDDEAEHLNQLRDKTPAEP
MSFE

Download         Length: 255 bp

>AT239780 NZ_CP094359:2583091-2583345 [Acidithiobacillus sp. YTS05]
ATGGCGACAGTCACCGTTAGAAATCTGCCGGACGAGGTGCATCGCGCGCTTCGTGTACGTGCGGCAACGCACGGCCGCAG
CACCGAGGCAGAAATCCGTGACATCCTCGAATCGACCGTGCGCCCATCGGAGCGGCTTCGCCTGGGCACGGCCTTGGCCG
AACTGGGCCGCCGTGTCGGGCTGACCGATGACGAAGCGGAGCATCTCAACCAGCTCCGCGACAAGACCCCGGCCGAGCCG
ATGAGCTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References