Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 200062..200679 Replicon chromosome
Accession NC_012917
Organism Pectobacterium carotovorum subsp. carotovorum PC1

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag PC1_RS00835 Protein ID WP_010281507.1
Coordinates 200500..200679 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID C6DHN2
Locus tag PC1_RS00830 Protein ID WP_012772908.1
Coordinates 200062..200472 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PC1_RS00815 195887..196930 - 1044 WP_012772905.1 DNA-binding transcriptional regulator CytR -
PC1_RS00820 197207..199405 - 2199 WP_012772906.1 primosomal protein N' -
PC1_RS00825 199720..199935 + 216 WP_012772907.1 50S ribosomal protein L31 -
PC1_RS00830 200062..200472 - 411 WP_012772908.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PC1_RS00835 200500..200679 - 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
PC1_RS00840 200777..201787 - 1011 WP_012772909.1 iron ABC transporter permease -
PC1_RS00845 201784..202746 - 963 WP_012772910.1 ABC transporter substrate-binding protein -
PC1_RS00850 202756..203553 - 798 WP_012772911.1 ABC transporter ATP-binding protein -
PC1_RS00855 203769..204086 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
PC1_RS00860 204274..205434 + 1161 WP_012772912.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T23978 WP_010281507.1 NC_012917:c200679-200500 [Pectobacterium carotovorum subsp. carotovorum PC1]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T23978 NC_012917:c200679-200500 [Pectobacterium carotovorum subsp. carotovorum PC1]
ATGGATAGCAGGACGTTAATCGCAGAAATCAAGGCCGATGGGTGGGAGCTGATACGAGTGAACGGAAGCCACCACCATTT
TATGCACCCCAGCAAACCGGGATTAGTCACAATCCCCCACCCCAAGAAAGATTTACCAATAGGTACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14621.52 Da        Isoelectric Point: 4.4493

>AT23978 WP_012772908.1 NC_012917:c200472-200062 [Pectobacterium carotovorum subsp. carotovorum PC1]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAITNAKEAITGHIELLVEMGQDIPTVSTVGQLAKRSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT23978 NC_012917:c200472-200062 [Pectobacterium carotovorum subsp. carotovorum PC1]
ATGTTTTATCCCATTGCAATTGAAGCAGGCGACGATACTCACGCATACGGCGTAACAGTACCAGATTTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCTATCACAAACGCTAAAGAAGCGATTACCGGACATATCGAGCTACTGGTTGAGA
TGGGTCAGGATATTCCCACCGTATCAACAGTAGGTCAGCTGGCAAAAAGGTCTGAGTATGCAGGGTACACGTGGGCGGTT
GTTGATATTGATGTAACTCGTTTAATGGGCGGCTCAGAAAAAATTAACGTTACATTGCCCAAATCGCTGATTGACCGCAT
TGATCGTTGCGTGGCGAGTAATCCAGAATTTAAAAGTCGTTCGGGTTTTCTTGCACAGGCGGCATTAGAGCGAATTTCGT
CTTCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure
AlphaFold DB C6DHN2

References