Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1848721..1849349 Replicon chromosome
Accession NZ_CP094359
Organism Acidithiobacillus sp. YTS05

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MQE22_RS09130 Protein ID WP_215870771.1
Coordinates 1848948..1849349 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MQE22_RS09125 Protein ID WP_215870770.1
Coordinates 1848721..1848951 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE22_RS09105 (MQE22_09105) 1844168..1844524 - 357 WP_215872986.1 response regulator -
MQE22_RS09110 (MQE22_09110) 1844521..1845861 - 1341 WP_215885763.1 ATP-binding protein -
MQE22_RS09115 (MQE22_09115) 1845858..1846430 - 573 WP_215870768.1 heme NO-binding domain-containing protein -
MQE22_RS09120 (MQE22_09120) 1846427..1848298 - 1872 WP_215870769.1 diguanylate cyclase -
MQE22_RS09125 (MQE22_09125) 1848721..1848951 + 231 WP_215870770.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MQE22_RS09130 (MQE22_09130) 1848948..1849349 + 402 WP_215870771.1 tRNA(fMet)-specific endonuclease VapC Toxin
MQE22_RS09135 (MQE22_09135) 1849512..1850093 - 582 WP_215870772.1 cytochrome b/b6 domain-containing protein -
MQE22_RS09140 (MQE22_09140) 1850063..1853155 - 3093 WP_226827030.1 efflux RND transporter permease subunit -
MQE22_RS09145 (MQE22_09145) 1853152..1854144 - 993 WP_215870773.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15147.53 Da        Isoelectric Point: 9.6239

>T239778 WP_215870771.1 NZ_CP094359:1848948-1849349 [Acidithiobacillus sp. YTS05]
VINYLLDTNICIFTIKRKPPEIREQFRRHHGQMAISAITLMELIYGAEKSQAPERNLAEIEHFTARLELLEFGSEAAKHT
GQIRAELTRIGKPISPYDQMIAGHARSRGLIVVTNNLREFARVPGLRVVDWVS

Download         Length: 402 bp

>T239778 NZ_LS483317:c2214224-2214120 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8621.71 Da        Isoelectric Point: 4.5557

>AT239778 WP_215870770.1 NZ_CP094359:1848721-1848951 [Acidithiobacillus sp. YTS05]
MQKATIFLSNRSQAVRLPKAIAFPADVKRVEVLTVGRTRILIPEGESWDSWFDNEGVSADFMEDREQPADQARESL

Download         Length: 231 bp

>AT239778 NZ_LS483317:2214026-2214064 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References