Detailed information of TA system TA239777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1641245..1641776
• Replicon: chromosome
• Accession: NZ_CP094359
• Organism: Acidithiobacillus sp. YTS05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MQE22_RS08095
• Protein ID: WP_255789505.1
• Coordinates: 1641245..1641526 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: MQE22_RS08100
• Protein ID: WP_255789507.1
• Coordinates: 1641513..1641776 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQE22_RS08070 (MQE22_08070)	1636490..1637482	-	993	WP_255789499.1	glycosyltransferase family 2 protein	-
MQE22_RS08075 (MQE22_08075)	1637527..1638393	-	867	WP_255789501.1	glycosyltransferase	-
MQE22_RS08080 (MQE22_08080)	1638560..1639840	-	1281	WP_255789502.1	flippase	-
MQE22_RS08085 (MQE22_08085)	1639960..1640526	-	567	WP_255789503.1	Uma2 family endonuclease	-
MQE22_RS08090 (MQE22_08090)	1640601..1641158	-	558	WP_255789504.1	Uma2 family endonuclease	-
MQE22_RS08095 (MQE22_08095)	1641245..1641526	-	282	WP_255789505.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MQE22_RS08100 (MQE22_08100)	1641513..1641776	-	264	WP_255789507.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MQE22_RS08105 (MQE22_08105)	1642000..1642194	-	195	WP_255789508.1	hypothetical protein	-
MQE22_RS08110 (MQE22_08110)	1642326..1642745	-	420	WP_255789509.1	putative toxin-antitoxin system toxin component, PIN family	-
MQE22_RS08115 (MQE22_08115)	1642745..1642984	-	240	WP_215871806.1	ribbon-helix-helix domain-containing protein	-
MQE22_RS08120 (MQE22_08120)	1643153..1643596	+	444	WP_215871807.1	putative toxin-antitoxin system toxin component, PIN family	-
MQE22_RS08125 (MQE22_08125)	1643593..1643805	+	213	WP_226827314.1	ribbon-helix-helix protein, CopG family	-
MQE22_RS08130 (MQE22_08130)	1643821..1644333	-	513	WP_215871809.1	ATP synthase F1 subunit epsilon	-
MQE22_RS08135 (MQE22_08135)	1644481..1645356	+	876	WP_226827312.1	energy transducer TonB	-
MQE22_RS08140 (MQE22_08140)	1645366..1645539	+	174	WP_215871810.1	hypothetical protein	-
MQE22_RS08145 (MQE22_08145)	1645536..1645916	-	381	WP_215871811.1	thioredoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10912.44 Da
• Isoelectric Point: 7.9857

>T239777 WP_255789505.1 NZ_CP094359:c1641526-1641245 [Acidithiobacillus sp. YTS05]
MRRIEYTGQFKRDYKREARGHHRATLEADLLPVVKALACDQPLEPRHHDHALTGDWKDHRDCHVKPDLVLIYRKPDNEVL
QLVRISSHSELGL

Nucleotide

• Length: 282 bp

>T239777 NZ_LS483317:c2155284-2155075 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACATCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAATTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTTTATTTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9448.86 Da
• Isoelectric Point: 4.8177

>AT239777 WP_255789507.1 NZ_CP094359:c1641776-1641513 [Acidithiobacillus sp. YTS05]
MSANAVVRARIDEHIKEEASAVLAAMGLTVSDAFRIMLTRIAREKALPFEPLVPNETTIAAIREARAGNLKSFDSVEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT239777 NZ_LS483317:c2155589-2155296 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGCTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA