Detailed information of TA system TA239776

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1433451..1433973
• Replicon: chromosome
• Accession: NZ_CP094359
• Organism: Acidithiobacillus sp. YTS05

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MQE22_RS07120
• Protein ID: WP_215871128.1
• Coordinates: 1433686..1433973 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MQE22_RS07115
• Protein ID: WP_215871129.1
• Coordinates: 1433451..1433696 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQE22_RS07090 (MQE22_07085)	1428675..1428941	-	267	WP_215871133.1	hypothetical protein	-
MQE22_RS07095 (MQE22_07090)	1429014..1429322	-	309	WP_215871132.1	hypothetical protein	-
MQE22_RS07100 (MQE22_07095)	1429345..1429839	-	495	WP_215871131.1	DsrE family protein	-
MQE22_RS07105 (MQE22_07100)	1429877..1430473	-	597	WP_226826866.1	cytochrome P460 family protein	-
MQE22_RS07110 (MQE22_07105)	1430659..1433400	+	2742	WP_215871130.1	type I restriction-modification enzyme R subunit C-terminal domain-containing protein	-
MQE22_RS07115 (MQE22_07110)	1433451..1433696	+	246	WP_215871129.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MQE22_RS07120 (MQE22_07115)	1433686..1433973	+	288	WP_215871128.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQE22_RS07125 (MQE22_07120)	1433970..1435511	+	1542	WP_255789436.1	restriction endonuclease subunit S	-
MQE22_RS07130 (MQE22_07125)	1435508..1436242	+	735	WP_255789437.1	hypothetical protein	-
MQE22_RS07135 (MQE22_07130)	1436239..1437075	+	837	WP_255789438.1	DUF3037 domain-containing protein	-
MQE22_RS07140 (MQE22_07135)	1437072..1437959	+	888	WP_255789439.1	GIY-YIG nuclease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-61)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11312.29 Da
• Isoelectric Point: 10.6226

>T239776 WP_215871128.1 NZ_CP094359:1433686-1433973 [Acidithiobacillus sp. YTS05]
MTYSLEFRDSAWKEWQKLDRLLREQFKAKLLERLENPRVESARLSGMPDCYKIKLRAAGYRLVYRIFDERVVVVVVAVGK
REDSAVYRKAKGRMK

Nucleotide

• Length: 288 bp

>T239776 NZ_LS483317:c2135697-2135335 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGATTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9005.33 Da
• Isoelectric Point: 4.3557

>AT239776 WP_215871129.1 NZ_CP094359:1433451-1433696 [Acidithiobacillus sp. YTS05]
MEILYTNASISISELKKNPSAVIEEADGFPVAVLNHNRPAAYLVPAAAFEAMIEKLDDIELVRMVKEREHEPTIKVSPDD
L

Nucleotide

• Length: 246 bp

>AT239776 NZ_LS483317:c2135864-2135694 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAACTCAA
CGAATGAATGA