Detailed information of TA system TA239773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 266598..267136
• Replicon: chromosome
• Accession: NZ_CP094359
• Organism: Acidithiobacillus sp. YTS05

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MQE22_RS01225
• Protein ID: WP_255789971.1
• Coordinates: 266598..266906 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: MQE22_RS01230
• Protein ID: WP_226827342.1
• Coordinates: 266921..267136 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQE22_RS01215 (MQE22_01215)	262239..263768	-	1530	WP_215872634.1	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-
MQE22_RS01220 (MQE22_01220)	263806..266316	-	2511	WP_255789969.1	glycogen/starch/alpha-glucan phosphorylase	-
MQE22_RS01225 (MQE22_01225)	266598..266906	-	309	WP_255789971.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MQE22_RS01230 (MQE22_01230)	266921..267136	-	216	WP_226827342.1	antitoxin MazE family protein	Antitoxin
MQE22_RS01235 (MQE22_01235)	267414..267800	+	387	WP_215872638.1	rhodanese-like domain-containing protein	-
MQE22_RS01240 (MQE22_01240)	267802..268746	-	945	WP_215872639.1	carbohydrate kinase family protein	-
MQE22_RS01245 (MQE22_01245)	268811..269446	+	636	WP_255789974.1	outer membrane beta-barrel protein	-
MQE22_RS01250 (MQE22_01250)	269559..270728	+	1170	WP_255789976.1	methionine adenosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-97)

Antitoxin

• Antitoxin MazE-like (5-66)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 10981.92 Da
• Isoelectric Point: 10.1046

>T239773 WP_255789971.1 NZ_CP094359:c266906-266598 [Acidithiobacillus sp. YTS05]
VTIAMQGDFGKPRPALVIQSNQFRDLGSITVLPITSTLIDAPLLRITVQPGTENGLQKPSQVMVNKAMTIKRDKVGPAFG
HIDANTLVEVERCLAVFLGIAK

Nucleotide

• Length: 309 bp

>T239773 NZ_LS483317:c874954-874766 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8304.34 Da
• Isoelectric Point: 5.0757

>AT239773 WP_226827342.1 NZ_CP094359:c267136-266921 [Acidithiobacillus sp. YTS05]
MAHVNQRVQKHREALRREGLRPVQIWVPDTRRPDFAEECRRQCLIVAQADSADTAMQQFMDEALADGWPEE

Nucleotide

• Length: 216 bp

>AT239773 NZ_LS483317:c875243-874983 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA