Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 170404..170984 Replicon chromosome
Accession NZ_CP094359
Organism Acidithiobacillus sp. YTS05

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MQE22_RS00770 Protein ID WP_215871373.1
Coordinates 170658..170984 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MQE22_RS00765 Protein ID WP_215871374.1
Coordinates 170404..170661 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQE22_RS00730 (MQE22_00730) 165991..166416 + 426 WP_215871380.1 OsmC family protein -
MQE22_RS00735 (MQE22_00735) 166417..166905 + 489 WP_215871379.1 Rrf2 family transcriptional regulator -
MQE22_RS00740 (MQE22_00740) 166922..167551 - 630 WP_215871378.1 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone monooxygenase -
MQE22_RS00745 (MQE22_00745) 167615..167926 + 312 WP_215871377.1 ferredoxin -
MQE22_RS00750 (MQE22_00750) 167926..168654 + 729 WP_215871376.1 alpha/beta fold hydrolase -
MQE22_RS00755 (MQE22_00755) 168635..169564 + 930 WP_255789924.1 ATP-binding cassette domain-containing protein -
MQE22_RS00760 (MQE22_00760) 169564..170337 + 774 WP_215871375.1 ABC transporter permease -
MQE22_RS00765 (MQE22_00765) 170404..170661 + 258 WP_215871374.1 antitoxin Antitoxin
MQE22_RS00770 (MQE22_00770) 170658..170984 + 327 WP_215871373.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MQE22_RS00780 (MQE22_00780) 171701..175282 - 3582 WP_215871372.1 type IV pilin biogenesis protein -
MQE22_RS00785 (MQE22_00785) 175279..175815 - 537 WP_255789928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11759.69 Da        Isoelectric Point: 9.1995

>T239772 WP_215871373.1 NZ_CP094359:170658-170984 [Acidithiobacillus sp. YTS05]
VKRGDIYLVSLDPTTGHEQSGSRPVLIVSPAEFNEVTRLPVILPITNGGEFSRRLGFAVPLTGIKTTGIVRCDQPRVIDL
AARHARKVDTLPAALMDEVLARVVTLFQ

Download         Length: 327 bp

>T239772 NZ_LS483317:368372-368548 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9137.46 Da        Isoelectric Point: 5.4394

>AT239772 WP_215871374.1 NZ_CP094359:170404-170661 [Acidithiobacillus sp. YTS05]
MHTTSLRKVGGSVMLAVPPAFLDQLHLQVGATVGLVVDHGCLVVNPHPRPRYTLAELLAASDYSQPQPADEREWVDAPAV
GNELL

Download         Length: 258 bp

>AT239772 NZ_LS483317:c368710-368536 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACACGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References