239769

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 6704..7184 Replicon plasmid p76-1
Accession NZ_CP094352
Organism Pseudomonas orientalis strain YB-76

Toxin (Protein)


Gene name pasB Uniprot ID S6W1B6
Locus tag MRY17_RS26200 Protein ID WP_017709581.1
Coordinates 6704..6976 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S6VUC4
Locus tag MRY17_RS26205 Protein ID WP_015062150.1
Coordinates 6960..7184 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRY17_RS26170 (MRY17_26170) 2571..2897 + 327 WP_074929282.1 hypothetical protein -
MRY17_RS26175 (MRY17_26175) 2894..5065 + 2172 WP_243353970.1 DotA/TraY family protein -
MRY17_RS26180 (MRY17_26180) 5102..5605 + 504 WP_017709584.1 hypothetical protein -
MRY17_RS26185 (MRY17_26185) 5633..5947 - 315 WP_024667340.1 hypothetical protein -
MRY17_RS26190 (MRY17_26190) 5937..6191 - 255 WP_080106675.1 hypothetical protein -
MRY17_RS26195 (MRY17_26195) 6232..6531 - 300 WP_024667341.1 plasmid mobilization protein MobA -
MRY17_RS26200 (MRY17_26200) 6704..6976 - 273 WP_017709581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MRY17_RS26205 (MRY17_26205) 6960..7184 - 225 WP_015062150.1 DUF6290 family protein Antitoxin
MRY17_RS26210 (MRY17_26210) 7718..7981 + 264 WP_243353971.1 hypothetical protein -
MRY17_RS26215 (MRY17_26215) 8790..9014 - 225 WP_074929272.1 hypothetical protein -
MRY17_RS26220 (MRY17_26220) 10284..11585 - 1302 WP_243353972.1 replication initiation protein -
MRY17_RS26225 (MRY17_26225) 11771..12004 - 234 WP_243353973.1 plasmid replication protein RepB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38519 38519


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Relaxosome protein TraY

(4-49)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10233.68 Da        Isoelectric Point: 8.4933

>T239769 WP_017709581.1 NZ_CP094352:c6976-6704 [Pseudomonas orientalis]
MTWRIEFDPAAEKELKELGDDAAKDVLKFLVGRITNQGEPHSIGSALKGSELGELWKYRVGDYRIVSNIQDVTLTILVVR
LSSQQRGYRR

Download         Length: 273 bp

>T239769 NZ_LS483316:c2546836-2546729 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8548.63 Da        Isoelectric Point: 4.3135

>AT239769 WP_015062150.1 NZ_CP094352:c7184-6960 [Pseudomonas orientalis]
MLAIRLAPEIEERLEALAARTGRTKTFYAREAILEHIDDLEDLYLAEQRLGEVRENRSETISLQDVIKSYDLAD

Download         Length: 225 bp

>AT239769 NZ_LS483316:2546652-2546712 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S6W1B6

Antitoxin

Source ID Structure
AlphaFold DB S6VUC4

References