Detailed information of TA system TA239766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3773106..3773670
• Replicon: chromosome
• Accession: NZ_CP094351
• Organism: Pseudomonas orientalis strain YB-76

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MRY17_RS16700
• Protein ID: WP_243353950.1
• Coordinates: 3773389..3773670 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MRY17_RS16695
• Protein ID: WP_181285462.1
• Coordinates: 3773106..3773393 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MRY17_RS16665 (MRY17_16665)	3768275..3769675	+	1401	WP_191952017.1	heavy metal sensor histidine kinase	-
MRY17_RS16670 (MRY17_16670)	3769682..3770128	-	447	WP_243352520.1	anti-virulence regulator CigR family protein	-
MRY17_RS16675 (MRY17_16675)	3770191..3770820	-	630	WP_243352521.1	pyroglutamyl-peptidase I	-
MRY17_RS16680 (MRY17_16680)	3770828..3771778	-	951	WP_181285461.1	DUF979 domain-containing protein	-
MRY17_RS16685 (MRY17_16685)	3771775..3772488	-	714	WP_065952927.1	DUF969 domain-containing protein	-
MRY17_RS16690 (MRY17_16690)	3772645..3772983	+	339	WP_243352522.1	hypothetical protein	-
MRY17_RS16695 (MRY17_16695)	3773106..3773393	+	288	WP_181285462.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MRY17_RS16700 (MRY17_16700)	3773389..3773670	+	282	WP_243353950.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MRY17_RS16705 (MRY17_16705)	3773864..3774157	+	294	WP_243352523.1	hypothetical protein	-
MRY17_RS16710 (MRY17_16710)	3774273..3775841	-	1569	WP_243352524.1	IS66 family transposase	-
MRY17_RS16715 (MRY17_16715)	3775903..3776238	-	336	WP_243352525.1	IS66 family insertion sequence element accessory protein TnpB	-
MRY17_RS16720 (MRY17_16720)	3776235..3776552	-	318	WP_213627872.1	transposase	-
MRY17_RS16725 (MRY17_16725)	3776862..3777149	+	288	WP_243352526.1	hypothetical protein	-
MRY17_RS16730 (MRY17_16730)	3777385..3777687	+	303	WP_243352527.1	hypothetical protein	-
MRY17_RS16735 (MRY17_16735)	3777770..3778033	+	264	WP_243352528.1	hypothetical protein	-
MRY17_RS16740 (MRY17_16740)	3778104..3778250	-	147	WP_164699508.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-71)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10920.79 Da
• Isoelectric Point: 10.4983

>T239766 WP_243353950.1 NZ_CP094351:3773389-3773670 [Pseudomonas orientalis]
IEYTVQWDPKALKELRKLDGTIRLQFLKKLQERQTGPRVPSDALHGMKDCYKIKLRSAGYRMVYRVEDERIVILVLAVGK
RERSSVYEQAGKR

Nucleotide

• Length: 282 bp

>T239766 NZ_LS483316:c2199201-2198992 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10129.53 Da
• Isoelectric Point: 4.1807

>AT239766 WP_181285462.1 NZ_CP094351:3773106-3773393 [Pseudomonas orientalis]
VQNILADVAVSVSELKKNPSSVLSGANGLPVAVLNHNRVVGYMVPANVYEAMVERLDELELVQLVKARLEANETPVQIAL
DDLIGEAEADIANGH

Nucleotide

• Length: 288 bp

>AT239766 NZ_LS483316:c2199506-2199213 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA