Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2310026..2310627 Replicon chromosome
Accession NZ_CP094351
Organism Pseudomonas orientalis strain YB-76

Toxin (Protein)


Gene name hicA Uniprot ID A0A4U3I3Z1
Locus tag MRY17_RS10385 Protein ID WP_057722035.1
Coordinates 2310376..2310627 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MRY17_RS10380 Protein ID WP_065884693.1
Coordinates 2310026..2310379 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRY17_RS10365 (MRY17_10365) 2305534..2307102 + 1569 WP_243353698.1 hypothetical protein -
MRY17_RS10370 (MRY17_10370) 2307458..2308813 + 1356 WP_191953472.1 MATE family efflux transporter -
MRY17_RS10375 (MRY17_10375) 2308854..2310047 + 1194 WP_243353699.1 MFS transporter -
MRY17_RS10380 (MRY17_10380) 2310026..2310379 - 354 WP_065884693.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MRY17_RS10385 (MRY17_10385) 2310376..2310627 - 252 WP_057722035.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9490.04 Da        Isoelectric Point: 10.0459

>T239764 WP_057722035.1 NZ_CP094351:c2310627-2310376 [Pseudomonas orientalis]
VSKNEKLLAKLLNEHMAFTWSELVTLLRRLGYTQIEGAGSRVKFDIGDPSALITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T239764 NZ_LS483316:c2079257-2079081 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 12737.61 Da        Isoelectric Point: 7.3241

>AT239764 WP_065884693.1 NZ_CP094351:c2310379-2310026 [Pseudomonas orientalis]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFKEAVDDYLATCQALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHCPAIG

Download         Length: 354 bp

>AT239764 NZ_LS483316:2078958-2079013 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U3I3Z1

Antitoxin

Source ID Structure

References