Detailed information of TA system TA239763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1852727..1853331
• Replicon: chromosome
• Accession: NZ_CP094351
• Organism: Pseudomonas orientalis strain YB-76

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MRY17_RS08275
• Protein ID: WP_181284637.1
• Coordinates: 1852727..1852915 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MRY17_RS08280
• Protein ID: WP_181284638.1
• Coordinates: 1852927..1853331 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MRY17_RS08250 (MRY17_08250)	1849084..1849620	+	537	WP_124422940.1	DsbE family thiol:disulfide interchange protein	-
MRY17_RS08255 (MRY17_08255)	1849617..1850090	+	474	WP_243353563.1	cytochrome c-type biogenesis protein CcmH	-
MRY17_RS08260 (MRY17_08260)	1850083..1851267	+	1185	WP_181284634.1	c-type cytochrome biogenesis protein CcmI	-
MRY17_RS08265 (MRY17_08265)	1851283..1851678	+	396	WP_181284635.1	hypothetical protein	-
MRY17_RS08270 (MRY17_08270)	1852035..1852601	+	567	WP_191955156.1	phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN	-
MRY17_RS08275 (MRY17_08275)	1852727..1852915	+	189	WP_181284637.1	type II toxin-antitoxin system HicA family toxin	Toxin
MRY17_RS08280 (MRY17_08280)	1852927..1853331	+	405	WP_181284638.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MRY17_RS08285 (MRY17_08285)	1853328..1854524	-	1197	WP_243353564.1	MFS transporter	-
MRY17_RS08290 (MRY17_08290)	1854833..1855837	-	1005	WP_181284640.1	sulfate ABC transporter substrate-binding protein	-
MRY17_RS08295 (MRY17_08295)	1855934..1856758	-	825	WP_124357697.1	ion transporter	-
MRY17_RS08300 (MRY17_08300)	1856790..1857665	-	876	WP_181284641.1	urea transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (11-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7134.32 Da
• Isoelectric Point: 11.5379

>T239763 WP_181284637.1 NZ_CP094351:1852727-1852915 [Pseudomonas orientalis]
VQSRLLIKESLEAGRVLDRVTGSHHLFTHRYNPYTIPVPHPKKDLPVGTVRSIRKRAGLFQF

Nucleotide

• Length: 189 bp

>T239763 NZ_LS483316:c1926522-1926370 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14644.56 Da
• Isoelectric Point: 4.4765

>AT239763 WP_181284638.1 NZ_CP094351:1852927-1853331 [Pseudomonas orientalis]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHILLQEIAAEGGVIPMPTSVATHHAHEDYAGMGWGM
LELDVSPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAALEKLVRS

Nucleotide

• Length: 405 bp

>AT239763 NZ_LS483316:c1927146-1926547 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA