239761

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1840370..1840861 Replicon chromosome
Accession NZ_CP094348
Organism Macrococcus armenti strain CCM 2609

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MRZ06_RS09770 Protein ID WP_224183481.1
Coordinates 1840370..1840720 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MRZ06_RS09775 Protein ID WP_224183482.1
Coordinates 1840721..1840861 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRZ06_RS09745 (MRZ06_09740) 1835481..1837616 - 2136 WP_243365648.1 Tex family protein -
MRZ06_RS09750 (MRZ06_09745) 1837692..1838460 - 769 Protein_1895 RNA polymerase sigma factor SigB -
MRZ06_RS09755 (MRZ06_09750) 1838465..1838908 - 444 WP_243365649.1 anti-sigma B factor RsbW -
MRZ06_RS09760 (MRZ06_09755) 1838914..1839237 - 324 WP_224183479.1 anti-sigma factor antagonist -
MRZ06_RS09765 (MRZ06_09760) 1839313..1840320 - 1008 WP_243365650.1 PP2C family protein-serine/threonine phosphatase -
MRZ06_RS09770 (MRZ06_09765) 1840370..1840720 - 351 WP_224183481.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MRZ06_RS09775 (MRZ06_09770) 1840721..1840861 - 141 WP_224183482.1 antitoxin MazE Antitoxin
MRZ06_RS09780 (MRZ06_09775) 1840923..1842065 - 1143 WP_243365651.1 alanine racemase -
MRZ06_RS09785 (MRZ06_09780) 1842106..1842447 - 342 WP_243365652.1 holo-ACP synthase -
MRZ06_RS09790 (MRZ06_09785) 1842389..1842913 - 525 WP_243365653.1 PH domain-containing protein -
MRZ06_RS09795 (MRZ06_09790) 1842897..1844408 - 1512 WP_243365654.1 PH domain-containing protein -
MRZ06_RS09800 (MRZ06_09795) 1844398..1844874 - 477 WP_243365655.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12717.88 Da        Isoelectric Point: 9.8410

>T239761 WP_224183481.1 NZ_CP094348:c1840720-1840370 [Macrococcus armenti]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKYSPTVIVAAITAKINKAKIPTHVEIGKTSHHLEKDSVILLEQIRT
IDKNRLIDHLTVLDKVKMKEVDVALAISLGLSIESE

Download         Length: 351 bp

>T239761 NZ_LS483316:c840759-840571 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5239.84 Da        Isoelectric Point: 3.8301

>AT239761 WP_224183482.1 NZ_CP094348:c1840861-1840721 [Macrococcus armenti]
MSQKLEQMLIEGYQSMAEINLSIASEHYILECEVNDNHQTLALDGE

Download         Length: 141 bp

>AT239761 NZ_LS483316:c841048-840788 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References