Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 3106973..3107647 | Replicon | chromosome |
| Accession | NZ_CP094346 | ||
| Organism | [Acidovorax] ebreus strain LS1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | MRB47_RS14460 | Protein ID | WP_252101038.1 |
| Coordinates | 3106973..3107392 (-) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A7X2LI96 |
| Locus tag | MRB47_RS14465 | Protein ID | WP_033945649.1 |
| Coordinates | 3107393..3107647 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MRB47_RS14420 (MRB47_14420) | 3102031..3102396 | + | 366 | WP_252101031.1 | mercury resistance co-regulator MerD | - |
| MRB47_RS14425 (MRB47_14425) | 3102393..3102611 | + | 219 | WP_252101032.1 | broad-spectrum mercury transporter MerE | - |
| MRB47_RS14430 (MRB47_14430) | 3103025..3103330 | + | 306 | WP_252102637.1 | transcriptional regulator | - |
| MRB47_RS14435 (MRB47_14435) | 3103575..3103805 | - | 231 | WP_252101033.1 | type I toxin-antitoxin system ptaRNA1 family toxin | - |
| MRB47_RS14440 (MRB47_14440) | 3103868..3104140 | - | 273 | WP_252101034.1 | hypothetical protein | - |
| MRB47_RS14445 (MRB47_14445) | 3104143..3105735 | - | 1593 | WP_252101035.1 | P-type conjugative transfer protein TrbL | - |
| MRB47_RS14450 (MRB47_14450) | 3105732..3106001 | - | 270 | WP_252101036.1 | entry exclusion lipoprotein TrbK | - |
| MRB47_RS14455 (MRB47_14455) | 3106017..3106802 | - | 786 | WP_252101037.1 | P-type conjugative transfer protein TrbJ | - |
| MRB47_RS14460 (MRB47_14460) | 3106973..3107392 | - | 420 | WP_252101038.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MRB47_RS14465 (MRB47_14465) | 3107393..3107647 | - | 255 | WP_033945649.1 | plasmid stabilization protein | Antitoxin |
| MRB47_RS14470 (MRB47_14470) | 3107715..3109523 | - | 1809 | WP_252101039.1 | relaxase/mobilization nuclease domain-containing protein | - |
| MRB47_RS14475 (MRB47_14475) | 3109558..3109968 | - | 411 | WP_252101040.1 | conjugal transfer transcriptional regulator TraJ | - |
| MRB47_RS14480 (MRB47_14480) | 3110300..3110578 | - | 279 | WP_252101041.1 | TraK family protein | - |
| MRB47_RS14485 (MRB47_14485) | 3111020..3111436 | - | 417 | Protein_2862 | helicase RepA family protein | - |
| MRB47_RS14490 (MRB47_14490) | 3111440..3111673 | - | 234 | WP_077056475.1 | plasmid-related protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3099192..3113076 | 13884 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15037.21 Da Isoelectric Point: 4.9006
>T239757 WP_252101038.1 NZ_CP094346:c3107392-3106973 [[Acidovorax] ebreus]
MIVLDTNVVSEAMKPEPDAAVRAWLNDQAAETLYLSSVTLAELLFGIRALPAGKRKNMLDRALNELLELFKDRVLPFDTD
AARRYADLAVTAKNGGRGFPTPDGYIAAVAASRGFIVASRDTSPYEAAGVAVINPWKDV
MIVLDTNVVSEAMKPEPDAAVRAWLNDQAAETLYLSSVTLAELLFGIRALPAGKRKNMLDRALNELLELFKDRVLPFDTD
AARRYADLAVTAKNGGRGFPTPDGYIAAVAASRGFIVASRDTSPYEAAGVAVINPWKDV
Download Length: 420 bp
>T239757 NZ_LS483314:c2433563-2433297 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9260.68 Da Isoelectric Point: 10.5807
>AT239757 WP_033945649.1 NZ_CP094346:c3107647-3107393 [[Acidovorax] ebreus]
MAILTVRNVPDDVHRALRVRAAQHGRSTEAEVREILAAVVKPEKRVRVGEALAAIGRKIGLTNEDFAVFESVRDKTPAKP
LSFD
MAILTVRNVPDDVHRALRVRAAQHGRSTEAEVREILAAVVKPEKRVRVGEALAAIGRKIGLTNEDFAVFESVRDKTPAKP
LSFD
Download Length: 255 bp
>AT239757 NZ_LS483314:c2433814-2433563 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|