Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6712934..6713439 Replicon chromosome
Accession NZ_CP094343
Organism Pseudomonas sp. M1

Toxin (Protein)


Gene name parE Uniprot ID W5IQ81
Locus tag PM1_RS29845 Protein ID WP_009614629.1
Coordinates 6713158..6713439 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID W5IQE2
Locus tag PM1_RS29840 Protein ID WP_009614631.1
Coordinates 6712934..6713161 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PM1_RS29820 (MRY70_29820) 6709555..6709956 - 402 WP_009614637.1 GFA family protein -
PM1_RS29825 (MRY70_29825) 6709968..6710699 - 732 WP_009614636.1 phytanoyl-CoA dioxygenase family protein -
PM1_RS29830 (MRY70_29830) 6710696..6711622 - 927 WP_009614635.1 LysR family transcriptional regulator -
PM1_RS29835 (MRY70_29835) 6711697..6712653 - 957 WP_009614633.1 agmatinase -
PM1_RS29840 (MRY70_29840) 6712934..6713161 + 228 WP_009614631.1 CopG family ribbon-helix-helix protein Antitoxin
PM1_RS29845 (MRY70_29845) 6713158..6713439 + 282 WP_009614629.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PM1_RS29850 (MRY70_29850) 6713699..6714427 + 729 WP_009614627.1 RcnB family protein -
PM1_RS29855 (MRY70_29855) 6714468..6714749 - 282 WP_009614626.1 DUF2218 domain-containing protein -
PM1_RS29860 (MRY70_29860) 6714847..6715764 + 918 WP_009614625.1 LysR family transcriptional regulator -
PM1_RS29865 (MRY70_29865) 6715823..6716278 + 456 WP_009614624.1 GNAT family N-acetyltransferase -
PM1_RS29870 (MRY70_29870) 6716275..6716892 - 618 WP_009614623.1 DUF1826 domain-containing protein -
PM1_RS29875 (MRY70_29875) 6716892..6718094 - 1203 WP_009614622.1 zinc metallochaperone GTPase ZigA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10251.74 Da        Isoelectric Point: 6.4614

>T239756 WP_009614629.1 NZ_CP094343:6713158-6713439 [Pseudomonas sp. M1]
MSLQWTHKAAADLDGLYDHYVVLIGPEKALKAIQDVVGQVKALADLSLSSVGRPSEVPGVRELPLERWPYQAAYRVKGRD
VQILRIDSVDNPG

Download         Length: 282 bp

>T239756 NZ_LS483314:c2122070-2121861 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8357.42 Da        Isoelectric Point: 6.6405

>AT239756 WP_009614631.1 NZ_CP094343:6712934-6713161 [Pseudomonas sp. M1]
MTTVISFRADDALAKALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGLADANAGHLLPHAEIEAKWGLA

Download         Length: 228 bp

>AT239756 NZ_LS483314:c2122375-2122082 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5D1B8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1GJG7

References