Detailed information of TA system TA239754

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 5776862..5777331
• Replicon: chromosome
• Accession: NZ_CP094343
• Organism: Pseudomonas sp. M1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PM1_RS25540
• Protein ID: WP_024128153.1
• Coordinates: 5777056..5777331 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W5IQM6
• Locus tag: PM1_RS25535
• Protein ID: WP_009617620.1
• Coordinates: 5776862..5777056 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PM1_RS25510 (MRY70_25510)	5771909..5773612	+	1704	WP_009617629.1	type IV-A pilus assembly ATPase PilB	-
PM1_RS25515 (MRY70_25515)	5773616..5774833	+	1218	WP_009617627.1	type II secretion system F family protein	-
PM1_RS25520 (MRY70_25520)	5774836..5775708	+	873	WP_009617626.1	A24 family peptidase	-
PM1_RS25525 (MRY70_25525)	5775782..5776390	+	609	WP_009617624.1	dephospho-CoA kinase	-
PM1_RS25530 (MRY70_25530)	5776387..5776596	+	210	WP_009617622.1	DNA gyrase inhibitor YacG	-
PM1_RS25535 (MRY70_25535)	5776862..5777056	+	195	WP_009617620.1	hypothetical protein	Antitoxin
PM1_RS25540 (MRY70_25540)	5777056..5777331	+	276	WP_024128153.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
PM1_RS25545 (MRY70_25545)	5777338..5777553	-	216	WP_009617618.1	hypothetical protein	-
PM1_RS25550 (MRY70_25550)	5777661..5778377	-	717	WP_009617616.1	energy-coupling factor ABC transporter permease	-
PM1_RS25555 (MRY70_25555)	5778374..5778850	-	477	WP_009617614.1	hypothetical protein	-
PM1_RS25560 (MRY70_25560)	5778853..5779269	-	417	WP_009617613.1	GNAT family N-acetyltransferase	-
PM1_RS25565 (MRY70_25565)	5779402..5780031	+	630	WP_009617612.1	DUF1780 domain-containing protein	-
PM1_RS25570 (MRY70_25570)	5780101..5780274	+	174	WP_009617611.1	DUF3094 family protein	-
PM1_RS25575 (MRY70_25575)	5780321..5781619	+	1299	WP_009617610.1	NAD(P)/FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	pilB / pilC / xcpA/pilD	5763639..5777553	13914

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10478.03 Da
• Isoelectric Point: 7.3551

>T239754 WP_024128153.1 NZ_CP094343:5777056-5777331 [Pseudomonas sp. M1]
VLSIIWRRSASDDLATILAYIANEDPQAARRLKERVESAVLPLAQHPYLYRHGRVPGTREVVIHPNYILVYRIDAECIEV
VSVLHSRQEYP

Nucleotide

• Length: 276 bp

>T239754 NZ_LS483314:c2048360-2048061 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7293.07 Da
• Isoelectric Point: 4.9890

>AT239754 WP_009617620.1 NZ_CP094343:5776862-5777056 [Pseudomonas sp. M1]
MSARLSPIVSEFETPEQAASHDRWFRQKVQKSLTDNQPGRPHDEVMVDMDAIIAQAEARRQGND

Nucleotide

• Length: 195 bp

>AT239754 NZ_LS483314:c2048572-2048363 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1A5D6N4