Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 5409997..5410570 Replicon chromosome
Accession NZ_CP094343
Organism Pseudomonas sp. M1

Toxin (Protein)


Gene name relE Uniprot ID W5IUR0
Locus tag PM1_RS23850 Protein ID WP_009618209.1
Coordinates 5410283..5410570 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5ISI7
Locus tag PM1_RS23845 Protein ID WP_009618210.1
Coordinates 5409997..5410296 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PM1_RS23815 (MRY70_23815) 5405149..5405367 + 219 WP_009461157.1 AlpA family transcriptional regulator -
PM1_RS23820 (MRY70_23820) 5405410..5406276 + 867 WP_009618216.1 ParA family protein -
PM1_RS23825 (MRY70_23825) 5406260..5406508 + 249 WP_009618214.1 hypothetical protein -
PM1_RS23830 (MRY70_23830) 5406501..5408144 + 1644 WP_009618213.1 ParB family protein -
PM1_RS23835 (MRY70_23835) 5408164..5408724 + 561 WP_009618212.1 DUF2857 domain-containing protein -
PM1_RS23840 (MRY70_23840) 5408727..5409869 + 1143 WP_009618211.1 STY4528 family pathogenicity island replication protein -
PM1_RS23845 (MRY70_23845) 5409997..5410296 + 300 WP_009618210.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PM1_RS23850 (MRY70_23850) 5410283..5410570 + 288 WP_009618209.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PM1_RS23855 (MRY70_23855) 5410599..5410790 + 192 WP_009618207.1 hypothetical protein -
PM1_RS23860 (MRY70_23860) 5410914..5411693 + 780 WP_009618206.1 TIGR03761 family integrating conjugative element protein -
PM1_RS23865 (MRY70_23865) 5411690..5412238 + 549 WP_009618205.1 DUF3158 family protein -
PM1_RS23870 (MRY70_23870) 5412235..5412618 + 384 WP_003141056.1 single-stranded DNA-binding protein -
PM1_RS23875 (MRY70_23875) 5412914..5414944 + 2031 WP_009618204.1 DNA topoisomerase III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5400554..5490677 90123


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10854.46 Da        Isoelectric Point: 8.4628

>T239752 WP_009618209.1 NZ_CP094343:5410283-5410570 [Pseudomonas sp. M1]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Download         Length: 288 bp

>T239752 NZ_LS483314:c839420-839232 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10816.46 Da        Isoelectric Point: 8.6579

>AT239752 WP_009618210.1 NZ_CP094343:5409997-5410296 [Pseudomonas sp. M1]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART

Download         Length: 300 bp

>AT239752 NZ_LS483314:c839709-839449 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R9QF16

Antitoxin

Source ID Structure
AlphaFold DB A0A5R9QE11

References