Detailed information of TA system TA239751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PfiT-PfiA/ParE(toxin)
• Location: 5379617..5380225
• Replicon: chromosome
• Accession: NZ_CP094343
• Organism: Pseudomonas sp. M1

Toxin (Protein)

• Gene name: PfiT
• Uniprot ID: W5IRQ0
• Locus tag: PM1_RS23675
• Protein ID: WP_009618255.1
• Coordinates: 5379878..5380225 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: PfiA
• Uniprot ID: -
• Locus tag: PM1_RS23670
• Protein ID: WP_081884705.1
• Coordinates: 5379617..5379868 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PM1_RS23650 (MRY70_23650)	5374815..5376056	-	1242	WP_009618263.1	aminotransferase class III-fold pyridoxal phosphate-dependent enzyme	-
PM1_RS23655 (MRY70_23655)	5376119..5377024	-	906	WP_009618261.1	LysR family transcriptional regulator	-
PM1_RS23660 (MRY70_23660)	5377081..5377617	-	537	WP_009618259.1	2,4'-dihydroxyacetophenone dioxygenase family protein	-
PM1_RS23665 (MRY70_23665)	5377743..5379158	-	1416	WP_009618257.1	amino acid permease	-
PM1_RS23670 (MRY70_23670)	5379617..5379868	+	252	WP_081884705.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PM1_RS23675 (MRY70_23675)	5379878..5380225	+	348	WP_009618255.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PM1_RS23680 (MRY70_23680)	5380589..5381194	+	606	WP_009618253.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
PM1_RS23685 (MRY70_23685)	5381290..5382762	+	1473	WP_009618251.1	DUF3375 domain-containing protein	-
PM1_RS23690 (MRY70_23690)	5382794..5383468	+	675	WP_009618249.1	DUF4194 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12949.77 Da
• Isoelectric Point: 4.6337

>T239751 WP_009618255.1 NZ_CP094343:5379878-5380225 [Pseudomonas sp. M1]
MSKLVIRLTDTAEQSIEDQVHHLAQFQGSQAALQSVLSLLDEIEEKISLTPQGYPISQQASLLGVLNYRELNTGPYRVFY
ELHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIG

Nucleotide

• Length: 348 bp

>T239751 NZ_LS483313:1051377-1051727 [Staphylococcus simulans]
ATGATGAGGAGAGGCGATGTTTATTTAGCTGATTTATCACCAGTGCAAGGTTCTGAACAAGGGGGAGTTAGACCTGTTGT
AATTATACAAAATGACACTGGCAATAAGTACAGTCCGACGGTAATTGTAGCCGCGATTACTGGGCGTATTAATAAGGCGA
AAATTCCAACACATGTTGAAATTGAAAAGAGTAAATACAAATTAGACAAAGATTCTGTTATATTACTTGAACAGATTAGA
ACAGTTGATAAAAAACGTTTGAAAGAGAAATTGACTTATCTTTCAGATGAGAAGATGAAAGAAATTGATAACGCGATTGG
AATTAGTTTAGGCTTGACACATAAAAATTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9500.82 Da
• Isoelectric Point: 8.4753

>AT239751 WP_081884705.1 NZ_CP094343:5379617-5379868 [Pseudomonas sp. M1]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVIESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFD
QPE

Nucleotide

• Length: 252 bp

>AT239751 NZ_LS483313:1051213-1051380 [Staphylococcus simulans]
ATGTCAACTTTTAATCAGAATAGAAGCTATAGTTTGGAACAGTCATTAAAAGAAGGCTATTCACAAATGGCTGATTTGAA
TCTCTCCCTAGCAACGGAGGCATTTTCAGTGGAATGTGAAGCCTGTGATTGCAATGAATCTTATCTTACATTTGATAAGG
ATGAATGA

Structures

Toxin

• AlphaFold DB: W5IRQ0