Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1811785..1813224 Replicon chromosome
Accession NZ_CP094343
Organism Pseudomonas sp. M1

Toxin (Protein)


Gene name - Uniprot ID W5IXK4
Locus tag PM1_RS08275 Protein ID WP_009620564.1
Coordinates 1811785..1812354 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W5IZU8
Locus tag PM1_RS08280 Protein ID WP_009620562.1
Coordinates 1812364..1813224 (+) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PM1_RS08270 (MRY70_08270) 1808057..1811533 - 3477 WP_009620566.1 hybrid sensor histidine kinase/response regulator -
PM1_RS08275 (MRY70_08275) 1811785..1812354 + 570 WP_009620564.1 GNAT family protein Toxin
PM1_RS08280 (MRY70_08280) 1812364..1813224 + 861 WP_009620562.1 AraC family transcriptional regulator Antitoxin
PM1_RS08285 (MRY70_08285) 1814117..1815991 + 1875 WP_009620560.1 MFS transporter -
PM1_RS08290 (MRY70_08290) 1816041..1816250 - 210 WP_009620558.1 cold-shock protein -
PM1_RS08295 (MRY70_08295) 1816442..1816756 - 315 WP_009620556.1 quaternary ammonium compound efflux SMR transporter SugE -
PM1_RS08300 (MRY70_08300) 1816900..1817844 - 945 WP_009620554.1 bile acid:sodium symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(14-146)

Antitoxin

DNA binding HTH domain, AraC-type

(197-274)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21064.37 Da        Isoelectric Point: 10.2120

>T239746 WP_009620564.1 NZ_CP094343:1811785-1812354 [Pseudomonas sp. M1]
MFRPSPITLQRGALRLEPMVEADVPDLVALAEANREALKFMSAPQRPDWYRNSLAEQREGRALPLVVRLGNQLVGTTRFM
DFLPALPACEIGGTWLDAAQHGTGLNASIKYLMLRQAFDNWKMVRVQLKTAASNLRSQRAIEKLGAVREGVLRNHRRLAG
GRLDDSVLYSITDLEWPQVKAALEAGFIG

Download         Length: 570 bp

>T239746 NZ_LS483311:c2569318-2569052 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31631.97 Da        Isoelectric Point: 8.7294

>AT239746 WP_009620562.1 NZ_CP094343:1812364-1813224 [Pseudomonas sp. M1]
MPLDSAQGERTRFWRAQELGGLELLHARFIEQRFAPHVHEGFALVLIEQGAQRFRHRGAEHLAPSGSLVLINPDEVHTGS
KAHEAGWLYRGFYPEIGQVGSVLDELELGGRGLPTFDASVLHDTELSRAFLHVHRLLESNASSLERQTCWREALLLLFQR
HARVPEARPAGQEPQAVARARELLAARLVEPPSLEELAAAVNLSPFHFARVFRKATGLPPHAWIKQRRLEQARALLKGGC
APASVAAQLGYADQSHLSRQFKQAYGVAPGEYRQACGRSGLPPGNL

Download         Length: 861 bp

>AT239746 NZ_LS483311:c2569575-2569318 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5DB72

Antitoxin

Source ID Structure
AlphaFold DB W5IZU8

References