Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1798681..1799820 Replicon chromosome
Accession NZ_CP094343
Organism Pseudomonas sp. M1

Toxin (Protein)


Gene name - Uniprot ID A0A1A9KFP9
Locus tag PM1_RS08235 Protein ID WP_009620578.1
Coordinates 1799050..1799820 (+) Length 257 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W5IZT9
Locus tag PM1_RS08230 Protein ID WP_009620580.1
Coordinates 1798681..1799049 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PM1_RS08195 (MRY70_08195) 1793876..1794712 - 837 WP_009620594.1 5'-nucleotidase, lipoprotein e(P4) family -
PM1_RS08200 (MRY70_08200) 1795006..1796055 + 1050 WP_009620592.1 diguanylate cyclase -
PM1_RS08205 (MRY70_08205) 1796043..1796414 - 372 WP_009620590.1 hypothetical protein -
PM1_RS08210 (MRY70_08210) 1796506..1796847 - 342 WP_009620588.1 carboxymuconolactone decarboxylase family protein -
PM1_RS08215 (MRY70_08215) 1796919..1797401 - 483 WP_009620586.1 GreA/GreB family elongation factor -
PM1_RS08220 (MRY70_08220) 1797530..1797961 + 432 WP_009620584.1 hypothetical protein -
PM1_RS08225 (MRY70_08225) 1797968..1798402 - 435 WP_024128552.1 RcnB family protein -
PM1_RS08230 (MRY70_08230) 1798681..1799049 + 369 WP_009620580.1 DUF2384 domain-containing protein Antitoxin
PM1_RS08235 (MRY70_08235) 1799050..1799820 + 771 WP_009620578.1 RES family NAD+ phosphorylase Toxin
PM1_RS08240 (MRY70_08240) 1799896..1800102 + 207 WP_009620576.1 hypothetical protein -
PM1_RS08245 (MRY70_08245) 1800627..1801991 + 1365 WP_161788527.1 DNA recombination protein RmuC -
PM1_RS08250 (MRY70_08250) 1802367..1803254 - 888 WP_009620572.1 metal-dependent hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(69-212)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-50)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 28862.03 Da        Isoelectric Point: 7.0428

>T239745 WP_009620578.1 NZ_CP094343:1799050-1799820 [Pseudomonas sp. M1]
MALDAGAELWRECRGEQAIAPLRGKLVRLVESQEQVATLQLVDTLEEQALLEELIETSKPHLPPSTETLHYLLKTPFRYP
PLRWGSRFGRRHEPSLFYAALRLETAMAEAAYYRFVLWEGMASPPPSGRILSEHASFEARFQVQRGIRLQAPPFDSYAER
LQDPRDYRLTQALGSAMRAAAVEAFEYRSARCPEGGLNAALFVPSAFVDKRPRNLMPWLCETTADYVAFKHAQVPGAPRL
FPRAGFLVEGDLPHPA

Download         Length: 771 bp

>T239745 NZ_LS483311:c2537628-2537521 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13381.67 Da        Isoelectric Point: 10.8284

>AT239745 WP_009620580.1 NZ_CP094343:1798681-1799049 [Pseudomonas sp. M1]
MSALIRETPSADLVLAKAVLAAREQLGMTQQELAAIVGVDRSAVSRWKSGGLRVGSKTGELALLLVRVYRALFALFGGNL
DDMRHFLRTPNRHLSGVPLQRMEQVQGLVQVVEYLDAIRGKI

Download         Length: 369 bp

>AT239745 NZ_LS483311:2537444-2537504 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9KFP9

Antitoxin

Source ID Structure
AlphaFold DB W5IZT9

References