Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 726173..726840 Replicon chromosome
Accession NZ_CP094343
Organism Pseudomonas sp. M1

Toxin (Protein)


Gene name VapC1 Uniprot ID W5ISM6
Locus tag PM1_RS03140 Protein ID WP_009613158.1
Coordinates 726173..726583 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID W5ISS6
Locus tag PM1_RS03145 Protein ID WP_009613156.1
Coordinates 726580..726840 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PM1_RS03120 (MRY70_03120) 722080..722613 + 534 WP_009613171.1 (2Fe-2S)-binding protein -
PM1_RS03125 (MRY70_03125) 722616..723851 + 1236 WP_009613170.1 cytochrome c -
PM1_RS03130 (MRY70_03130) 723853..724821 + 969 WP_024128102.1 XdhC family protein -
PM1_RS03135 (MRY70_03135) 724818..725423 + 606 WP_009613168.1 nucleotidyltransferase family protein -
PM1_RS03140 (MRY70_03140) 726173..726583 - 411 WP_009613158.1 type II toxin-antitoxin system VapC family toxin Toxin
PM1_RS03145 (MRY70_03145) 726580..726840 - 261 WP_009613156.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PM1_RS03150 (MRY70_03150) 726923..728047 - 1125 WP_009613154.1 class I SAM-dependent methyltransferase -
PM1_RS03155 (MRY70_03155) 728176..728952 + 777 WP_009613152.1 ferredoxin--NADP reductase -
PM1_RS03160 (MRY70_03160) 729141..730694 + 1554 WP_009613147.1 TerC family protein -
PM1_RS03165 (MRY70_03165) 730712..731125 - 414 WP_009613146.1 large-conductance mechanosensitive channel protein MscL -
PM1_RS03170 (MRY70_03170) 731317..731559 + 243 WP_009613144.1 YdcH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(11-49)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15448.80 Da        Isoelectric Point: 7.1891

>T239743 WP_009613158.1 NZ_CP094343:c726583-726173 [Pseudomonas sp. M1]
VKYLLDTNILIYLLKNRPESVARRVNALPADAGLCMSFFTYAELLKGAERSTRRSEVLRQLERLTRQVPVVYDGTPRLCE
HYATQFTRLKLAGTPIGANDLWIACHALALEATLVTHNTREFERIDGLCLEDWAAE

Download         Length: 411 bp

>T239743 NZ_LS483311:c2252931-2252827 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9789.91 Da        Isoelectric Point: 4.2182

>AT239743 WP_009613156.1 NZ_CP094343:c726840-726580 [Pseudomonas sp. M1]
MSSPTLPSRVFMNGNSQAVRIPQEFRLDASRVEIRRQANGDLVIHPLPEDRGEALLQALSGFDDEFIEALEEGQREQPPM
QEREEL

Download         Length: 261 bp

>AT239743 NZ_LS483311:2252734-2252772 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z0IIB3

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5D6X2

References