Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 703126..703700 Replicon chromosome
Accession NZ_CP094343
Organism Pseudomonas sp. M1

Toxin (Protein)


Gene name vapC Uniprot ID W5ISV0
Locus tag PM1_RS03045 Protein ID WP_009613187.1
Coordinates 703335..703700 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID W5ISP5
Locus tag PM1_RS03040 Protein ID WP_009613188.1
Coordinates 703126..703341 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PM1_RS03020 (MRY70_03020) 698269..699075 + 807 WP_009613192.1 taurine ABC transporter ATP-binding protein -
PM1_RS03025 (MRY70_03025) 699065..699883 + 819 WP_009613191.1 ABC transporter permease subunit -
PM1_RS03030 (MRY70_03030) 700071..700907 + 837 WP_009613190.1 taurine dioxygenase -
PM1_RS03035 (MRY70_03035) 701033..703057 + 2025 WP_009613189.1 oligopeptide transporter, OPT family -
PM1_RS03040 (MRY70_03040) 703126..703341 + 216 WP_009613188.1 CopG family transcriptional regulator Antitoxin
PM1_RS03045 (MRY70_03045) 703335..703700 + 366 WP_009613187.1 type II toxin-antitoxin system VapC family toxin Toxin
PM1_RS03050 (MRY70_03050) 703688..704413 - 726 WP_009613186.1 hypothetical protein -
PM1_RS03055 (MRY70_03055) 704410..704592 - 183 WP_009613185.1 hypothetical protein -
PM1_RS03060 (MRY70_03060) 704589..705737 - 1149 WP_009613184.1 PepSY domain-containing protein -
PM1_RS03065 (MRY70_03065) 705745..708156 - 2412 WP_009613183.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13389.50 Da        Isoelectric Point: 7.0127

>T239742 WP_009613187.1 NZ_CP094343:703335-703700 [Pseudomonas sp. M1]
MVKALFDTNILIDYLNGHQQARDELRRYDDPAISIVTWMEVMIGATPATAAATRAFLDSFALVPLDAPVAERAVAVRQAL
RVKLPDAIIKASAEVQGRLLVTRNTRDFPVDDAGVRLPYRL

Download         Length: 366 bp

>T239742 NZ_LS483311:c2195687-2195478 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8033.94 Da        Isoelectric Point: 4.7616

>AT239742 WP_009613188.1 NZ_CP094343:703126-703341 [Pseudomonas sp. M1]
MRTLVDIPAEHLEALNALGEQQQQSRAALIREAVAEYLVRHRRQDAEAAFGLWNGSAGDGLAYQEKVREEW

Download         Length: 216 bp

>AT239742 NZ_LS483311:c2195992-2195699 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W5ISV0

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5D6Z2

References