Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 703126..703700 | Replicon | chromosome |
Accession | NZ_CP094343 | ||
Organism | Pseudomonas sp. M1 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | W5ISV0 |
Locus tag | PM1_RS03045 | Protein ID | WP_009613187.1 |
Coordinates | 703335..703700 (+) | Length | 122 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | W5ISP5 |
Locus tag | PM1_RS03040 | Protein ID | WP_009613188.1 |
Coordinates | 703126..703341 (+) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PM1_RS03020 (MRY70_03020) | 698269..699075 | + | 807 | WP_009613192.1 | taurine ABC transporter ATP-binding protein | - |
PM1_RS03025 (MRY70_03025) | 699065..699883 | + | 819 | WP_009613191.1 | ABC transporter permease subunit | - |
PM1_RS03030 (MRY70_03030) | 700071..700907 | + | 837 | WP_009613190.1 | taurine dioxygenase | - |
PM1_RS03035 (MRY70_03035) | 701033..703057 | + | 2025 | WP_009613189.1 | oligopeptide transporter, OPT family | - |
PM1_RS03040 (MRY70_03040) | 703126..703341 | + | 216 | WP_009613188.1 | CopG family transcriptional regulator | Antitoxin |
PM1_RS03045 (MRY70_03045) | 703335..703700 | + | 366 | WP_009613187.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
PM1_RS03050 (MRY70_03050) | 703688..704413 | - | 726 | WP_009613186.1 | hypothetical protein | - |
PM1_RS03055 (MRY70_03055) | 704410..704592 | - | 183 | WP_009613185.1 | hypothetical protein | - |
PM1_RS03060 (MRY70_03060) | 704589..705737 | - | 1149 | WP_009613184.1 | PepSY domain-containing protein | - |
PM1_RS03065 (MRY70_03065) | 705745..708156 | - | 2412 | WP_009613183.1 | TonB-dependent receptor | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 122 a.a. Molecular weight: 13389.50 Da Isoelectric Point: 7.0127
>T239742 WP_009613187.1 NZ_CP094343:703335-703700 [Pseudomonas sp. M1]
MVKALFDTNILIDYLNGHQQARDELRRYDDPAISIVTWMEVMIGATPATAAATRAFLDSFALVPLDAPVAERAVAVRQAL
RVKLPDAIIKASAEVQGRLLVTRNTRDFPVDDAGVRLPYRL
MVKALFDTNILIDYLNGHQQARDELRRYDDPAISIVTWMEVMIGATPATAAATRAFLDSFALVPLDAPVAERAVAVRQAL
RVKLPDAIIKASAEVQGRLLVTRNTRDFPVDDAGVRLPYRL
Download Length: 366 bp
>T239742 NZ_LS483311:c2195687-2195478 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG
Antitoxin
Download Length: 72 a.a. Molecular weight: 8033.94 Da Isoelectric Point: 4.7616
>AT239742 WP_009613188.1 NZ_CP094343:703126-703341 [Pseudomonas sp. M1]
MRTLVDIPAEHLEALNALGEQQQQSRAALIREAVAEYLVRHRRQDAEAAFGLWNGSAGDGLAYQEKVREEW
MRTLVDIPAEHLEALNALGEQQQQSRAALIREAVAEYLVRHRRQDAEAAFGLWNGSAGDGLAYQEKVREEW
Download Length: 216 bp
>AT239742 NZ_LS483311:c2195992-2195699 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | W5ISV0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1A5D6Z2 |