Detailed information of TA system TA023974

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4792800..4794373
• Replicon: chromosome
• Accession: NC_012912
• Organism: Dickeya zeae Ech1591

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: C6CR19
• Locus tag: DD1591_RS21105
• Protein ID: WP_015848526.1
• Coordinates: 4792800..4794119 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: DD1591_RS21110
• Protein ID: WP_015848527.1
• Coordinates: 4794119..4794373 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD1591_RS21095	4788595..4789464	-	870	WP_015848524.1	DNA damage-inducible protein D	-
DD1591_RS21100	4789495..4792296	-	2802	WP_015848525.1	DEAD/DEAH box helicase family protein	-
DD1591_RS21105	4792800..4794119	-	1320	WP_015848526.1	type II toxin-antitoxin system HipA family toxin	Toxin
DD1591_RS21110	4794119..4794373	-	255	WP_015848527.1	helix-turn-helix domain-containing protein	Antitoxin
DD1591_RS21115	4794911..4795528	+	618	WP_015848528.1	recombinase family protein	-
DD1591_RS21120	4795525..4795848	-	324	WP_015848529.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4782450..4809196	26746

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49457.47 Da
• Isoelectric Point: 7.0148

>T23974 WP_015848526.1 NC_012912:c4794119-4792800 [Dickeya chrysanthemi Ech1591]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDGELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASNKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTEMANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T23974 NC_012912:c4794119-4792800 [Dickeya chrysanthemi Ech1591]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTGGCACAACCGGGCAGCCGTCCCATCTCACTTTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACTCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGACGTTCCAGATGTCAGGCGAATCGACTACAAAGCACTTTCCGATGGCGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGAGCGCAAGAAAAGACAGCG
CTGCTCTATCTCGATGGCCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATTGGTAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGTCATGGAGGACCAGGGATCACTGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCGGCCACCGATGGCCATGCAAAGAATTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAACAAGGGAAAGAAGTACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCGAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAAATGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACACAGCAATTGCCAGCAGGCTTCCCCGATACCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCCGGCTGATAAAGGGCTGGGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9319.70 Da
• Isoelectric Point: 7.9834

>AT23974 WP_015848527.1 NC_012912:c4794373-4794119 [Dickeya chrysanthemi Ech1591]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFEINPESTKLETLFKILAALELSVDIKPRNESSESPALGW
KEEW

Nucleotide

• Length: 255 bp

>AT23974 NC_012912:c4794373-4794119 [Dickeya chrysanthemi Ech1591]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGATCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCAGCACTCGAATTGTCAGTGGATATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATTGGGCTGG
AAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: C6CR19