Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1771..2318 Replicon plasmid p2
Accession NZ_CP094341
Organism Escherichia coli strain W224N

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MQV61_RS25820 Protein ID WP_248784994.1
Coordinates 2040..2318 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag MQV61_RS25815 Protein ID WP_049144636.1
Coordinates 1771..2040 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQV61_RS25810 (1) 1..858 + 858 WP_230137315.1 incFII family plasmid replication initiator RepA -
MQV61_RS25815 (1771) 1771..2040 + 270 WP_049144636.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
MQV61_RS25820 (2040) 2040..2318 + 279 WP_248784994.1 type II toxin-antitoxin system toxin YacB Toxin
MQV61_RS25825 (2364) 2364..3212 + 849 WP_012881117.1 3'-5' exonuclease -
MQV61_RS25830 (3329) 3329..3811 + 483 WP_001311056.1 hypothetical protein -
MQV61_RS25835 (3840) 3840..4916 - 1077 WP_077252865.1 maltoporin -
MQV61_RS25840 (4917) 4917..5324 - 408 Protein_6 IS5-like element IS903B family transposase -
MQV61_RS25845 (5404) 5404..6279 - 876 WP_001617865.1 extended-spectrum class A beta-lactamase CTX-M-14 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-14 - 1..74517 74517
- flank IS/Tn blaCTX-M-14 - 5404..7791 2387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10818.44 Da        Isoelectric Point: 7.2753

>T239738 WP_248784994.1 NZ_CP094341:2040-2318 [Escherichia coli]
MEVFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSACSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWEKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T239738 NZ_LS483311:1928555-1928650 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10266.61 Da        Isoelectric Point: 7.2057

>AT239738 WP_049144636.1 NZ_CP094341:1771-2040 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQIEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT239738 NZ_LS483311:c1928735-1928678 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References