Detailed information of TA system TA239733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4758198..4759123
• Replicon: chromosome
• Accession: NZ_CP094339
• Organism: Escherichia coli strain W224N

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: MQV61_RS23380
• Protein ID: WP_014640052.1
• Coordinates: 4758198..4758584 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: MQV61_RS23385
• Protein ID: WP_024174200.1
• Coordinates: 4758614..4759123 (-)
• Length: 170 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQV61_RS23325 (4753246)	4753246..4753608	+	363	WP_000135680.1	protein YfdP	-
MQV61_RS23330 (4753674)	4753674..4754498	+	825	WP_000081287.1	DUF2303 family protein	-
MQV61_RS23335 (4754626)	4754626..4755162	+	537	WP_032340541.1	5'-deoxynucleotidase	-
MQV61_RS23340 (4755153)	4755153..4755503	+	351	WP_032340539.1	hypothetical protein	-
MQV61_RS23345 (4755500)	4755500..4756099	+	600	WP_032340538.1	ead/Ea22-like family protein	-
MQV61_RS23350 (4756101)	4756101..4756292	+	192	WP_016236813.1	hypothetical protein	-
MQV61_RS23355 (4756295)	4756295..4756609	+	315	Protein_4578	DUF551 domain-containing protein	-
MQV61_RS23360 (4756856)	4756856..4757047	+	192	WP_229430275.1	DUF551 domain-containing protein	-
MQV61_RS23365 (4757047)	4757047..4757619	+	573	WP_001061345.1	3'-5' exonuclease	-
MQV61_RS23370 (4757656)	4757656..4757937	+	282	WP_001093916.1	pyocin activator PrtN family protein	-
MQV61_RS23375 (4757985)	4757985..4758158	-	174	WP_000390072.1	hypothetical protein	-
MQV61_RS23380 (4758198)	4758198..4758584	-	387	WP_014640052.1	hypothetical protein	Toxin
MQV61_RS23385 (4758614)	4758614..4759123	-	510	WP_024174200.1	Panacea domain-containing protein	Antitoxin
MQV61_RS23390 (4759657)	4759657..4760172	+	516	WP_000416264.1	zinc uptake transcriptional repressor Zur	-
MQV61_RS23395 (4760214)	4760214..4760423	-	210	WP_001296638.1	CsbD family protein	-
MQV61_RS23400 (4760539)	4760539..4761864	-	1326	WP_001296637.1	MATE family efflux transporter DinF	-
MQV61_RS23405 (4761937)	4761937..4762545	-	609	WP_000646078.1	transcriptional repressor LexA	-
MQV61_RS23410 (4762655)	4762655..4763023	-	369	WP_000002899.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4741165..4762545	21380

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (6-116)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T239733 WP_014640052.1 NZ_CP094339:c4758584-4758198 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T239733 NZ_LS483310:c2405598-2405491 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Protein

• Length: 170 a.a.
• Molecular weight: 19559.39 Da
• Isoelectric Point: 5.3338

>AT239733 WP_024174200.1 NZ_CP094339:c4759123-4758614 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Nucleotide

• Length: 510 bp

>AT239733 NZ_LS483310:2405414-2405474 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA