Detailed information of TA system TA023973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 4242498..4243474
• Replicon: chromosome
• Accession: NC_012912
• Organism: Dickeya zeae Ech1591

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: DD1591_RS18610
• Protein ID: WP_015848061.1
• Coordinates: 4242498..4243013 (-)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: C6CMA7
• Locus tag: DD1591_RS18615
• Protein ID: WP_015848062.1
• Coordinates: 4243013..4243474 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD1591_RS18590	4237698..4238606	-	909	WP_015848057.1	homocysteine S-methyltransferase family protein	-
DD1591_RS18595	4238994..4241132	+	2139	WP_015848058.1	anaerobic ribonucleoside-triphosphate reductase	-
DD1591_RS18600	4241231..4241695	+	465	WP_015848059.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
DD1591_RS18605	4241762..4242214	-	453	WP_015848060.1	YhbP family protein	-
DD1591_RS18610	4242498..4243013	-	516	WP_015848061.1	PIN domain-containing protein	Toxin
DD1591_RS18615	4243013..4243474	-	462	WP_015848062.1	helix-turn-helix domain-containing protein	Antitoxin
DD1591_RS18620	4243659..4243961	+	303	Protein_3688	hypothetical protein	-
DD1591_RS18625	4244043..4245569	-	1527	WP_015848063.1	type I-E CRISPR-associated protein Cse1/CasA	-
DD1591_RS18630	4246304..4247227	+	924	WP_015848064.1	aminoimidazole riboside kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-131)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19197.06 Da
• Isoelectric Point: 4.7706

>T23973 WP_015848061.1 NC_012912:c4243013-4242498 [Dickeya chrysanthemi Ech1591]
MTHTPYPVVLDACVIYPSLLRDLLIHLGLTGLYQPKWTAIIEDEWQRNLLANRPDLTPEQISRTSELMNKAVPDAMITGF
EPLIPGIVLPDPDDRHVVAAAVRGNADIIVTFNLKDFPQPSLNNFGIEAQHPDDFMTDLFDLNQALVLSAVNKQRRNMKR
PPKSVGEYLDA

Nucleotide

• Length: 516 bp

>T23973 NC_012912:c4243013-4242498 [Dickeya chrysanthemi Ech1591]
ATGACACACACGCCTTATCCCGTAGTATTAGATGCTTGCGTAATTTATCCATCTCTCCTACGTGATTTATTAATCCACTT
AGGGCTAACGGGGCTGTATCAGCCCAAATGGACGGCTATCATCGAGGATGAATGGCAGCGCAATCTACTGGCGAATAGAC
CGGATTTAACCCCGGAGCAAATCTCTCGGACAAGCGAGCTGATGAATAAGGCGGTTCCTGATGCGATGATTACAGGGTTC
GAACCGCTCATTCCAGGCATCGTACTTCCTGATCCTGATGATCGTCATGTGGTTGCGGCCGCCGTTCGCGGTAATGCAGA
CATTATCGTGACGTTTAACCTGAAGGATTTTCCCCAGCCATCGCTCAATAACTTCGGCATTGAAGCACAACACCCGGATG
ACTTCATGACAGACCTGTTCGATTTGAATCAGGCACTTGTGTTATCTGCCGTAAATAAGCAGCGCCGTAACATGAAAAGA
CCGCCCAAATCTGTCGGTGAGTACCTGGATGCGTGA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17014.38 Da
• Isoelectric Point: 6.2229

>AT23973 WP_015848062.1 NC_012912:c4243474-4243013 [Dickeya chrysanthemi Ech1591]
MTNSILDSLSLPAPGEIEAAVRGQRELAAYLSTKMETQKISIQDADNNTRQIELPTSSLTLLMSILGELAMGNAVQVVPV
HAELTTQEAANILNVSRPHLVKLLEDGKLPFHKTGRHRRVLFANLMDYKHQRDNESSRAMQELADHSQELGLY

Nucleotide

• Length: 462 bp

>AT23973 NC_012912:c4243474-4243013 [Dickeya chrysanthemi Ech1591]
ATGACAAACTCAATTCTTGATAGCCTGAGCCTTCCGGCACCGGGGGAGATTGAGGCGGCTGTGCGTGGACAAAGGGAGCT
TGCTGCCTATCTCTCCACGAAGATGGAAACACAAAAAATTTCGATTCAGGATGCAGATAACAACACTCGCCAGATCGAAT
TACCGACGTCGTCACTGACGCTGCTGATGTCGATTTTAGGTGAGCTGGCCATGGGTAATGCGGTTCAGGTTGTTCCCGTA
CATGCTGAGTTAACAACGCAGGAAGCAGCCAATATTCTGAATGTTTCACGTCCTCACCTGGTGAAGCTTTTGGAAGATGG
GAAGCTGCCTTTTCATAAAACCGGTCGTCACCGCCGCGTGCTTTTCGCTAACCTGATGGACTATAAACACCAACGGGATA
ATGAAAGCAGTAGAGCAATGCAGGAATTGGCTGACCATAGTCAGGAGCTCGGACTCTACTAA

Structures

Antitoxin

• AlphaFold DB: C6CMA7