Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3741990..3742608 Replicon chromosome
Accession NZ_CP094339
Organism Escherichia coli strain W224N

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag MQV61_RS18565 Protein ID WP_001291435.1
Coordinates 3742390..3742608 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag MQV61_RS18560 Protein ID WP_000344800.1
Coordinates 3741990..3742364 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQV61_RS18550 (3737080) 3737080..3738273 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MQV61_RS18555 (3738296) 3738296..3741445 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
MQV61_RS18560 (3741990) 3741990..3742364 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
MQV61_RS18565 (3742390) 3742390..3742608 + 219 WP_001291435.1 HHA domain-containing protein Toxin
MQV61_RS18570 (3742782) 3742782..3743333 + 552 WP_000102543.1 maltose O-acetyltransferase -
MQV61_RS18575 (3743449) 3743449..3743919 + 471 WP_000136192.1 YlaC family protein -
MQV61_RS18580 (3744083) 3744083..3745633 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
MQV61_RS18585 (3745675) 3745675..3746028 - 354 WP_000878140.1 DUF1428 domain-containing protein -
MQV61_RS18595 (3746407) 3746407..3746718 + 312 WP_000409908.1 MGMT family protein -
MQV61_RS18600 (3746749) 3746749..3747321 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T239727 WP_001291435.1 NZ_CP094339:3742390-3742608 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T239727 NZ_LS483310:c785585-785397 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT239727 WP_000344800.1 NZ_CP094339:3741990-3742364 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT239727 NZ_LS483310:c785874-785614 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References