Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ataRT/DUF1778(antitoxin) |
| Location | 4193806..4194548 | Replicon | chromosome |
| Accession | NC_012912 | ||
| Organism | Dickeya zeae Ech1591 | ||
Toxin (Protein)
| Gene name | ataT | Uniprot ID | E0SIC1 |
| Locus tag | DD1591_RS18395 | Protein ID | WP_013316117.1 |
| Coordinates | 4194069..4194548 (+) | Length | 160 a.a. |
Antitoxin (Protein)
| Gene name | ataR | Uniprot ID | A0A3N0G0N1 |
| Locus tag | DD1591_RS18390 | Protein ID | WP_019843650.1 |
| Coordinates | 4193806..4194078 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DD1591_RS18380 | 4190063..4191397 | - | 1335 | WP_015848019.1 | type II toxin-antitoxin system HipA family toxin | - |
| DD1591_RS21820 | 4191402..4191707 | - | 306 | WP_015848020.1 | helix-turn-helix transcriptional regulator | - |
| DD1591_RS18385 | 4192028..4193284 | - | 1257 | WP_015848021.1 | tyrosine-type recombinase/integrase | - |
| DD1591_RS18390 | 4193806..4194078 | + | 273 | WP_019843650.1 | DUF1778 domain-containing protein | Antitoxin |
| DD1591_RS18395 | 4194069..4194548 | + | 480 | WP_013316117.1 | GNAT family N-acetyltransferase | Toxin |
| DD1591_RS18400 | 4194821..4195036 | - | 216 | WP_050570377.1 | helix-turn-helix domain-containing protein | - |
| DD1591_RS18405 | 4195132..4195398 | + | 267 | WP_015848023.1 | helix-turn-helix domain-containing protein | - |
| DD1591_RS18410 | 4195622..4197667 | - | 2046 | WP_015848024.1 | AAA family ATPase | - |
| DD1591_RS18415 | 4197660..4198199 | - | 540 | WP_015848025.1 | ash family protein | - |
| DD1591_RS18420 | 4198196..4198396 | - | 201 | WP_026357784.1 | AlpA family transcriptional regulator | - |
| DD1591_RS18425 | 4198399..4199280 | - | 882 | WP_015848026.1 | integrase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4177729..4204689 | 26960 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 160 a.a. Molecular weight: 17564.34 Da Isoelectric Point: 9.5367
>T23972 WP_013316117.1 NC_012912:4194069-4194548 [Dickeya chrysanthemi Ech1591]
VGITAPELLLPQHAVVDFHCSEPSLNEWLKRKALKNQTLGASRTFVVCEAGTQRVVGFYALASGSIQRQVAPGAFRRNMP
DPIPVLVLGRLAVDERYQRMGIGAGLLKDAVLRSRNVAQQVGNKALLVHALSDEAKAFYQYWGFVPSEIQEHTLLLSLW
VGITAPELLLPQHAVVDFHCSEPSLNEWLKRKALKNQTLGASRTFVVCEAGTQRVVGFYALASGSIQRQVAPGAFRRNMP
DPIPVLVLGRLAVDERYQRMGIGAGLLKDAVLRSRNVAQQVGNKALLVHALSDEAKAFYQYWGFVPSEIQEHTLLLSLW
Download Length: 480 bp
>T23972 NC_012912:4194069-4194548 [Dickeya chrysanthemi Ech1591]
GTGGGAATAACGGCACCTGAATTATTGCTGCCTCAACATGCAGTTGTGGATTTTCATTGTTCCGAGCCGTCATTGAATGA
ATGGCTGAAACGCAAGGCGTTAAAAAATCAGACGCTGGGCGCTTCACGCACCTTCGTGGTGTGTGAAGCCGGCACACAGC
GTGTGGTGGGGTTCTATGCCCTCGCGTCGGGTAGCATCCAGCGTCAGGTTGCACCGGGCGCATTCCGGCGCAATATGCCT
GACCCCATTCCTGTTCTGGTACTTGGCCGATTAGCCGTTGATGAACGTTATCAACGCATGGGGATCGGTGCCGGGCTTCT
GAAAGATGCGGTACTCCGCTCCCGCAATGTAGCGCAGCAGGTAGGCAACAAAGCATTATTGGTACATGCGTTATCTGATG
AGGCAAAAGCGTTCTACCAATACTGGGGTTTTGTCCCGTCAGAAATACAGGAACACACCTTATTATTATCGTTATGGTAA
GTGGGAATAACGGCACCTGAATTATTGCTGCCTCAACATGCAGTTGTGGATTTTCATTGTTCCGAGCCGTCATTGAATGA
ATGGCTGAAACGCAAGGCGTTAAAAAATCAGACGCTGGGCGCTTCACGCACCTTCGTGGTGTGTGAAGCCGGCACACAGC
GTGTGGTGGGGTTCTATGCCCTCGCGTCGGGTAGCATCCAGCGTCAGGTTGCACCGGGCGCATTCCGGCGCAATATGCCT
GACCCCATTCCTGTTCTGGTACTTGGCCGATTAGCCGTTGATGAACGTTATCAACGCATGGGGATCGGTGCCGGGCTTCT
GAAAGATGCGGTACTCCGCTCCCGCAATGTAGCGCAGCAGGTAGGCAACAAAGCATTATTGGTACATGCGTTATCTGATG
AGGCAAAAGCGTTCTACCAATACTGGGGTTTTGTCCCGTCAGAAATACAGGAACACACCTTATTATTATCGTTATGGTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10388.86 Da Isoelectric Point: 4.6702
>AT23972 WP_019843650.1 NC_012912:4193806-4194078 [Dickeya chrysanthemi Ech1591]
MRTETKEMPINIRAKASQRELIDVAAKLLSKSRTEFILDAACREAEDVLLDQRLFLVNDEQYDAFIQVLESPVTDNPRVN
ALLNRKSPWE
MRTETKEMPINIRAKASQRELIDVAAKLLSKSRTEFILDAACREAEDVLLDQRLFLVNDEQYDAFIQVLESPVTDNPRVN
ALLNRKSPWE
Download Length: 273 bp
>AT23972 NC_012912:4193806-4194078 [Dickeya chrysanthemi Ech1591]
ATGCGAACAGAGACAAAAGAAATGCCGATTAATATTCGTGCTAAAGCATCACAGCGGGAGCTGATTGATGTCGCTGCTAA
ATTGCTGTCGAAATCAAGAACAGAGTTTATCCTTGATGCTGCCTGCCGTGAGGCTGAGGATGTGTTGTTGGATCAACGGC
TGTTTCTGGTCAATGATGAACAATATGATGCTTTCATTCAGGTGCTGGAATCACCTGTCACAGATAATCCGCGTGTGAAT
GCATTACTGAACAGGAAATCTCCGTGGGAATAA
ATGCGAACAGAGACAAAAGAAATGCCGATTAATATTCGTGCTAAAGCATCACAGCGGGAGCTGATTGATGTCGCTGCTAA
ATTGCTGTCGAAATCAAGAACAGAGTTTATCCTTGATGCTGCCTGCCGTGAGGCTGAGGATGTGTTGTTGGATCAACGGC
TGTTTCTGGTCAATGATGAACAATATGATGCTTTCATTCAGGTGCTGGAATCACCTGTCACAGATAATCCGCGTGTGAAT
GCATTACTGAACAGGAAATCTCCGTGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3N0G158 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3N0G0N1 |