Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4190063..4191707 Replicon chromosome
Accession NC_012912
Organism Dickeya zeae Ech1591

Toxin (Protein)


Gene name hipA Uniprot ID C6CLK2
Locus tag DD1591_RS18380 Protein ID WP_015848019.1
Coordinates 4190063..4191397 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID C6CLK4
Locus tag DD1591_RS21820 Protein ID WP_015848020.1
Coordinates 4191402..4191707 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD1591_RS18365 4186140..4187022 + 883 Protein_3636 integrase domain-containing protein -
DD1591_RS18370 4187025..4187225 + 201 WP_026357784.1 AlpA family transcriptional regulator -
DD1591_RS21815 4187222..4187758 + 537 WP_015848017.1 ash family protein -
DD1591_RS18375 4187751..4189787 + 2037 WP_015848018.1 AAA family ATPase -
DD1591_RS18380 4190063..4191397 - 1335 WP_015848019.1 type II toxin-antitoxin system HipA family toxin Toxin
DD1591_RS21820 4191402..4191707 - 306 WP_015848020.1 helix-turn-helix transcriptional regulator Antitoxin
DD1591_RS18385 4192028..4193284 - 1257 WP_015848021.1 tyrosine-type recombinase/integrase -
DD1591_RS18390 4193806..4194078 + 273 WP_019843650.1 DUF1778 domain-containing protein -
DD1591_RS18395 4194069..4194548 + 480 WP_013316117.1 GNAT family N-acetyltransferase -
DD1591_RS18400 4194821..4195036 - 216 WP_050570377.1 helix-turn-helix domain-containing protein -
DD1591_RS18405 4195132..4195398 + 267 WP_015848023.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4177729..4204689 26960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 50931.05 Da        Isoelectric Point: 6.1911

>T23971 WP_015848019.1 NC_012912:c4191397-4190063 [Dickeya chrysanthemi Ech1591]
MPRTQQRLAIWMNGIQVGFWEKSRGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQIWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGAIQLLNGNEEPTDLFSVKYRPLCDAEIAAILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHERQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEDQKVLVVERF
DRRWSSDQQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMTILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
IAIEPRGRYHLTPLYDVLSAWPVIGPRNNQISWQKCKLAMAVRGSSNYYHLYRIQRRHWVNHGELTGLGRRQVEAMMDDI
IFRTPEVIERVSSLLPESFSPELAECVFDGMRQQCGRLQELHRK

Download         Length: 1335 bp

>T23971 NC_012912:c4191397-4190063 [Dickeya chrysanthemi Ech1591]
ATGCCTCGAACACAACAGCGTTTAGCAATATGGATGAATGGAATTCAAGTGGGATTCTGGGAAAAGAGCCGAGGCGAAGA
TAGGTTGCAATATCTTCCCGAATGGATCGCTGATGAACAAGGAAGACCTTTATCGCTTTCTTTGCTTTTCACCCCCGGTA
ATCAGATTTGGCGGGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCGACGCGTTACCACGCTGATAGCCTTGAGCCTTTTGATCTGTTGGCTGAGCTGGGGAGAGACTGTGTTGGTGCGATACA
GTTGCTGAATGGTAATGAGGAGCCTACAGATCTCTTTTCCGTAAAGTATCGCCCGCTTTGTGACGCAGAGATTGCCGCTA
TATTGCGTAATACAACAGCGGCATTGTTGCCAGGTCGGCAGGATGATACTGACGATTTACGTTTATCGATTGCCGGTGCG
CAGGAAAAAACGGCTTTACTCTGGCATGAAAGGCAATGGTGTTTGCCAGAAGGGAGTACCCCTACGACGCATATTTTCAA
GTTACCACTCGGGCTAGTGGGTAATATGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTGTGTTCTTTGATCC
TTAAGGAATATGGAATTCCTGTTGCAAAAACACAGATTGCGCAGTTTGAAGATCAGAAAGTATTGGTTGTTGAGCGTTTT
GACAGAAGATGGTCAAGCGATCAGCAATGGATCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTCTGGGTGTTTCCCC
GCTACGAAAATACCAGTCTGATGGTGGGCCGGGGATTTCCGATATTATGACCATACTGAGTCATTCAGAGCAGGCAGAGC
AGGACAAAGCGCAGTTTTTCAGGGCGCAAATTATTTTCTGGCTGATAGCGGCTACTGATGGGCATGCCAAAAATTTCAGT
ATCGCTATTGAGCCACGAGGTCGCTATCACCTTACGCCTCTTTATGATGTTTTATCGGCATGGCCGGTCATTGGTCCGCG
TAATAACCAGATTTCCTGGCAGAAGTGCAAGCTGGCAATGGCTGTTCGGGGTAGTAGTAATTATTACCATCTGTACAGAA
TTCAACGGCGGCATTGGGTCAATCATGGTGAATTAACTGGTCTGGGTAGACGACAGGTTGAAGCCATGATGGATGATATT
ATCTTCAGGACACCTGAGGTTATTGAACGTGTATCTTCGTTGCTGCCTGAGTCATTCTCACCAGAGCTTGCGGAATGTGT
TTTTGACGGTATGCGACAACAGTGTGGTCGGTTACAAGAATTGCACCGTAAATAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11313.11 Da        Isoelectric Point: 10.5325

>AT23971 WP_015848020.1 NC_012912:c4191707-4191402 [Dickeya chrysanthemi Ech1591]
MNTVYPLKTLNQLRPLLIGFRKAKGLTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTVLGVEVVLSSGPRVHFSM
SSSTMEEPEKPIDSPARREKW

Download         Length: 306 bp

>AT23971 NC_012912:c4191707-4191402 [Dickeya chrysanthemi Ech1591]
ATGAATACAGTCTATCCGTTGAAAACCTTGAATCAGTTGCGCCCATTGCTGATTGGCTTTCGCAAAGCTAAAGGACTGAC
GCAAAAAGACGTGTCTGAAAGGTTAGGTGTAACACAACAAACCTATGCCCGTTTGGAAGCAAACCCCGGAAGTGCCAGTA
TTGAGCGCTTGTTTAAAGTGCTCACCGTTCTGGGGGTTGAGGTGGTGCTGTCTTCTGGACCAAGAGTACATTTCTCGATG
TCGTCCTCAACAATGGAAGAGCCAGAAAAGCCAATAGACTCACCCGCCAGACGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C6CLK2

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2R984

References