Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2098558..2099036 Replicon chromosome
Accession NZ_CP094339
Organism Escherichia coli strain W224N

Toxin (Protein)


Gene name parE_1 Uniprot ID D8A5B3
Locus tag MQV61_RS09920 Protein ID WP_000936799.1
Coordinates 2098558..2098845 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D8A5B4
Locus tag MQV61_RS09925 Protein ID WP_000100899.1
Coordinates 2098845..2099036 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQV61_RS09890 (2095077) 2095077..2095298 - 222 WP_000560231.1 cell division protein FtsZ -
MQV61_RS09895 (2095344) 2095344..2096192 - 849 WP_000935606.1 Rha family phage regulatory protein -
MQV61_RS09900 (2096760) 2096760..2096981 + 222 WP_000202161.1 hypothetical protein -
MQV61_RS09910 (2097829) 2097829..2098122 - 294 WP_097494701.1 hypothetical protein -
MQV61_RS09915 (2098134) 2098134..2098286 - 153 WP_000379609.1 DUF1391 family protein -
MQV61_RS09920 (2098558) 2098558..2098845 - 288 WP_000936799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQV61_RS09925 (2098845) 2098845..2099036 - 192 WP_000100899.1 hypothetical protein Antitoxin
MQV61_RS09930 (2099064) 2099064..2099465 - 402 WP_001329851.1 helix-turn-helix domain-containing protein -
MQV61_RS09935 (2099575) 2099575..2099847 + 273 WP_000887447.1 YdaS family helix-turn-helix protein -
MQV61_RS09940 (2099831) 2099831..2100256 + 426 WP_000693918.1 toxin YdaT family protein -
MQV61_RS09945 (2100328) 2100328..2101398 + 1071 WP_001262355.1 hypothetical protein -
MQV61_RS09950 (2101439) 2101439..2101864 + 426 WP_001151152.1 DUF977 family protein -
MQV61_RS09955 (2102039) 2102039..2102704 + 666 WP_000150294.1 epoxyqueuosine reductase QueH -
MQV61_RS09960 (2102942) 2102942..2103097 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
MQV61_RS09965 (2103265) 2103265..2103543 + 279 WP_024193993.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2088614..2107698 19084


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10929.85 Da        Isoelectric Point: 10.1360

>T239708 WP_000936799.1 NZ_CP094339:c2098845-2098558 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVATSSIE
IANIVHARRQFPFPI

Download         Length: 288 bp

>T239708 NZ_LS483308:c2011482-2011231 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7035.80 Da        Isoelectric Point: 4.0270

>AT239708 WP_000100899.1 NZ_CP094339:c2099036-2098845 [Escherichia coli]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT239708 NZ_LS483308:c2011241-2011068 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8A5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A161RC07

References