Detailed information of TA system TA023970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4178496..4179023
• Replicon: chromosome
• Accession: NC_012912
• Organism: Dickeya zeae Ech1591

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DD1591_RS18330
• Protein ID: WP_038921507.1
• Coordinates: 4178496..4178771 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D2C2R6
• Locus tag: DD1591_RS18335
• Protein ID: WP_012883160.1
• Coordinates: 4178775..4179023 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD1591_RS18315	4174308..4175213	-	906	WP_015848006.1	hypothetical protein	-
DD1591_RS18320	4175210..4177594	-	2385	WP_015848007.1	dynamin family protein	-
DD1591_RS21795	4177729..4178412	+	684	Protein_3625	IS1 family transposase	-
DD1591_RS18330	4178496..4178771	-	276	WP_038921507.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DD1591_RS18335	4178775..4179023	-	249	WP_012883160.1	ribbon-helix-helix domain-containing protein	Antitoxin
DD1591_RS18340	4179134..4179966	-	833	Protein_3628	DUF4942 domain-containing protein	-
DD1591_RS18345	4180084..4180398	-	315	WP_015848011.1	TA system toxin CbtA family protein	-
DD1591_RS21800	4180397..4180567	+	171	WP_153248409.1	hypothetical protein	-
DD1591_RS18350	4180726..4181598	+	873	WP_015848012.1	HNH endonuclease	-
DD1591_RS21805	4181759..4182907	-	1149	WP_015848013.1	DUF87 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4177729..4204689	26960
	-	flank	IS/Tn	-	-	4177729..4177929	200

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11222.53 Da
• Isoelectric Point: 5.1578

>T23970 WP_038921507.1 NC_012912:c4178771-4178496 [Dickeya chrysanthemi Ech1591]
MEILWTQKAQDDLERIYRFASQYSRQHADDVLDRLFIGTTELVDHPRIGVSQTRYEPREVRKILFDDYEVHYEIQHNTIY
IIDLWHTREER

Nucleotide

• Length: 276 bp

>T23970 NC_012912:c4178771-4178496 [Dickeya chrysanthemi Ech1591]
ATGGAAATACTTTGGACACAAAAGGCACAGGATGACCTAGAGCGTATTTATCGGTTTGCCAGCCAGTACAGTCGGCAGCA
TGCTGACGATGTGTTAGATCGCCTGTTCATCGGAACAACAGAACTTGTTGATCATCCAAGAATCGGTGTATCTCAGACAA
GATATGAACCCCGTGAGGTGAGAAAAATTCTGTTTGATGATTACGAGGTTCACTATGAAATTCAGCACAACACTATTTAT
ATCATCGATCTTTGGCATACACGAGAGGAGCGTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9020.34 Da
• Isoelectric Point: 6.4653

>AT23970 WP_012883160.1 NC_012912:c4179023-4178775 [Dickeya chrysanthemi Ech1591]
MGQPAKQTISAQIPAELAAAVESLAIELDRSKSWVIKEALTAMIEERERQHQRILQGLADVDAGRVVNHADVLDFANKLK
KS

Nucleotide

• Length: 249 bp

>AT23970 NC_012912:c4179023-4178775 [Dickeya chrysanthemi Ech1591]
ATGGGACAGCCCGCAAAACAGACTATTAGTGCTCAGATACCCGCCGAGCTTGCTGCTGCGGTTGAAAGCCTGGCTATTGA
ATTGGATAGGTCGAAAAGTTGGGTGATTAAGGAAGCATTGACCGCAATGATCGAAGAGAGAGAACGTCAGCATCAACGGA
TTTTGCAAGGCCTTGCTGATGTTGATGCTGGAAGGGTGGTAAACCATGCTGATGTTCTCGATTTTGCCAATAAACTGAAA
AAGTCGTAA

Structures

Antitoxin

• AlphaFold DB: A0A375A6R5