Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4411976..4412757 | Replicon | chromosome |
| Accession | NZ_CP094332 | ||
| Organism | Salmonella enterica subsp. enterica strain 3018683606 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | MQF88_RS21835 | Protein ID | WP_000626099.1 |
| Coordinates | 4411976..4412467 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | MQF88_RS21840 | Protein ID | WP_001110452.1 |
| Coordinates | 4412464..4412757 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MQF88_RS21795 (4407162) | 4407162..4407404 | - | 243 | WP_197603740.1 | hypothetical protein | - |
| MQF88_RS21800 (4407401) | 4407401..4407757 | - | 357 | WP_033567083.1 | hypothetical protein | - |
| MQF88_RS21805 (4407754) | 4407754..4408626 | - | 873 | WP_033567082.1 | ParA family protein | - |
| MQF88_RS21810 (4408817) | 4408817..4408894 | - | 78 | Protein_4270 | helix-turn-helix domain-containing protein | - |
| MQF88_RS21815 (4408985) | 4408985..4409317 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| MQF88_RS21820 (4409389) | 4409389..4409766 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| MQF88_RS21825 (4410799) | 4410799..4410873 | + | 75 | Protein_4273 | porin family protein | - |
| MQF88_RS21830 (4410976) | 4410976..4411728 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| MQF88_RS21835 (4411976) | 4411976..4412467 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| MQF88_RS21840 (4412464) | 4412464..4412757 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| MQF88_RS21845 (4413074) | 4413074..4413295 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| MQF88_RS21850 (4413560) | 4413560..4414435 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| MQF88_RS21855 (4414432) | 4414432..4414719 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| MQF88_RS21860 (4414742) | 4414742..4414957 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| MQF88_RS21865 (4414965) | 4414965..4415234 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| MQF88_RS21870 (4415528) | 4415528..4416433 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T239689 WP_000626099.1 NZ_CP094332:c4412467-4411976 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T239689 NZ_LS483303:1947238-1947341 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT239689 WP_001110452.1 NZ_CP094332:c4412757-4412464 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT239689 NZ_LS483303:c1947379-1947111 [Escherichia coli]
AAAGTCAGCGAAGGGAATGTTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGTTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|