Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4411976..4412757 Replicon chromosome
Accession NZ_CP094332
Organism Salmonella enterica subsp. enterica strain 3018683606

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag MQF88_RS21835 Protein ID WP_000626099.1
Coordinates 4411976..4412467 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag MQF88_RS21840 Protein ID WP_001110452.1
Coordinates 4412464..4412757 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQF88_RS21795 (4407162) 4407162..4407404 - 243 WP_197603740.1 hypothetical protein -
MQF88_RS21800 (4407401) 4407401..4407757 - 357 WP_033567083.1 hypothetical protein -
MQF88_RS21805 (4407754) 4407754..4408626 - 873 WP_033567082.1 ParA family protein -
MQF88_RS21810 (4408817) 4408817..4408894 - 78 Protein_4270 helix-turn-helix domain-containing protein -
MQF88_RS21815 (4408985) 4408985..4409317 - 333 WP_001165471.1 MerR family transcriptional regulator -
MQF88_RS21820 (4409389) 4409389..4409766 + 378 WP_000916345.1 EthD family reductase -
MQF88_RS21825 (4410799) 4410799..4410873 + 75 Protein_4273 porin family protein -
MQF88_RS21830 (4410976) 4410976..4411728 + 753 WP_000842434.1 non-specific acid phosphatase -
MQF88_RS21835 (4411976) 4411976..4412467 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
MQF88_RS21840 (4412464) 4412464..4412757 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
MQF88_RS21845 (4413074) 4413074..4413295 + 222 WP_001576552.1 hypothetical protein -
MQF88_RS21850 (4413560) 4413560..4414435 + 876 WP_000921674.1 AraC family transcriptional regulator -
MQF88_RS21855 (4414432) 4414432..4414719 + 288 WP_001269916.1 transcriptional regulator RtsB -
MQF88_RS21860 (4414742) 4414742..4414957 + 216 WP_001595136.1 hypothetical protein -
MQF88_RS21865 (4414965) 4414965..4415234 + 270 WP_010989096.1 hypothetical protein -
MQF88_RS21870 (4415528) 4415528..4416433 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T239689 WP_000626099.1 NZ_CP094332:c4412467-4411976 [Salmonella enterica subsp. enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T239689 NZ_LS483303:1947238-1947341 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT239689 WP_001110452.1 NZ_CP094332:c4412757-4412464 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT239689 NZ_LS483303:c1947379-1947111 [Escherichia coli]
AAAGTCAGCGAAGGGAATGTTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References