239683

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3449748..3450368 Replicon chromosome
Accession NZ_CP094332
Organism Salmonella enterica subsp. enterica strain 3018683606

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MQF88_RS17155 Protein ID WP_001280991.1
Coordinates 3450150..3450368 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MQF88_RS17150 Protein ID WP_000344807.1
Coordinates 3449748..3450122 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQF88_RS17140 (3444887) 3444887..3446080 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MQF88_RS17145 (3446103) 3446103..3449252 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MQF88_RS17150 (3449748) 3449748..3450122 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MQF88_RS17155 (3450150) 3450150..3450368 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MQF88_RS17160 (3450547) 3450547..3451098 + 552 WP_001278792.1 maltose O-acetyltransferase -
MQF88_RS17165 (3451215) 3451215..3451685 + 471 WP_000136181.1 YlaC family protein -
MQF88_RS17170 (3451741) 3451741..3451881 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MQF88_RS17175 (3451887) 3451887..3452147 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MQF88_RS17180 (3452372) 3452372..3453922 + 1551 WP_000213139.1 EAL domain-containing protein -
MQF88_RS17190 (3454153) 3454153..3454542 + 390 WP_000961285.1 MGMT family protein -
MQF88_RS17195 (3454575) 3454575..3455144 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T239683 WP_001280991.1 NZ_CP094332:3450150-3450368 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T239683 NZ_LS483302:c2446622-2446515 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT239683 WP_000344807.1 NZ_CP094332:3449748-3450122 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT239683 NZ_LS483302:2446438-2446498 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References