Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 838328..838988 Replicon chromosome
Accession NZ_CP094332
Organism Salmonella enterica subsp. enterica strain 3018683606

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MQF88_RS04030 Protein ID WP_000244756.1
Coordinates 838575..838988 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MQF88_RS04025 Protein ID WP_000351186.1
Coordinates 838328..838594 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQF88_RS04005 (834256) 834256..835689 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
MQF88_RS04010 (835848) 835848..836159 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MQF88_RS04015 (836323) 836323..836982 + 660 WP_000250289.1 hemolysin III family protein -
MQF88_RS04020 (837098) 837098..838078 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
MQF88_RS04025 (838328) 838328..838594 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MQF88_RS04030 (838575) 838575..838988 + 414 WP_000244756.1 protein YgfX Toxin
MQF88_RS04035 (839041) 839041..839562 - 522 WP_001055885.1 flavodoxin FldB -
MQF88_RS04040 (839675) 839675..840571 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MQF88_RS04045 (840595) 840595..841308 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MQF88_RS04050 (841314) 841314..843047 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T239671 WP_000244756.1 NZ_CP094332:838575-838988 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T239671 NZ_LS483301:c2243031-2242669 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT239671 WP_000351186.1 NZ_CP094332:838328-838594 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT239671 NZ_LS483301:c2243198-2243028 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References