Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206529..207289 Replicon chromosome
Accession NZ_CP094332
Organism Salmonella enterica subsp. enterica strain 3018683606

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag MQF88_RS00965 Protein ID WP_000533909.1
Coordinates 206804..207289 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag MQF88_RS00960 Protein ID WP_000965886.1
Coordinates 206529..206816 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQF88_RS00935 (201824) 201824..202126 + 303 WP_000605590.1 YsaB family lipoprotein -
MQF88_RS00940 (202265) 202265..203176 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
MQF88_RS00945 (203186) 203186..205255 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
MQF88_RS00950 (205437) 205437..205712 + 276 Protein_189 IS3 family transposase -
MQF88_RS00955 (205884) 205884..206351 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
MQF88_RS00960 (206529) 206529..206816 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
MQF88_RS00965 (206804) 206804..207289 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
MQF88_RS00970 (207661) 207661..208200 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
MQF88_RS00975 (208374) 208374..208586 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MQF88_RS00980 (208875) 208875..209165 - 291 WP_000455790.1 HTH-type transcriptional regulator -
MQF88_RS00985 (209604) 209604..210314 + 711 WP_000190524.1 DUF3053 domain-containing protein -
MQF88_RS00990 (210364) 210364..211338 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
MQF88_RS00995 (211557) 211557..212219 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T239668 WP_000533909.1 NZ_CP094332:206804-207289 [Salmonella enterica subsp. enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T239668 NZ_LS483301:1958596-1958691 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT239668 WP_000965886.1 NZ_CP094332:206529-206816 [Salmonella enterica subsp. enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT239668 NZ_LS483301:c1958778-1958719 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References