Detailed information of TA system TA239666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 22084..22709
• Replicon: plasmid unnamed2
• Accession: NZ_CP094325
• Organism: Edwardsiella anguillarum strain Eco2413

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MQ084_RS19925
• Protein ID: WP_098142458.1
• Coordinates: 22311..22709 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MQ084_RS19920
• Protein ID: WP_098142459.1
• Coordinates: 22084..22311 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ084_RS19920 (MQ084_19900)	22084..22311	+	228	WP_098142459.1	toxin-antitoxin system antitoxin VapB	Antitoxin
MQ084_RS19925 (MQ084_19905)	22311..22709	+	399	WP_098142458.1	tRNA(fMet)-specific endonuclease VapC	Toxin
MQ084_RS19930 (MQ084_19910)	22787..24991	-	2205	WP_283292376.1	type IV conjugative transfer system coupling protein TraD	-
MQ084_RS19935 (MQ084_19915)	25078..25575	-	498	WP_283292378.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	papD / papC	1..91494	91494

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14835.08 Da
• Isoelectric Point: 7.9270

>T239666 WP_098142458.1 NZ_CP094325:22311-22709 [Edwardsiella anguillarum]
MLKYMLDTNICIFTLKNRPAQVRDKFNLHHNQMCISSITLMELIYGAEKSQSPEHNLAVIEGFIARLTVLNYDAPAAAHS
GQLRAEQARLGQPIGPYDQMIAGHARSQGLILVTNNTREFARVSGLRIEDWV

Nucleotide

• Length: 399 bp

>T239666 NZ_LS483301:c877923-877735 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8384.40 Da
• Isoelectric Point: 4.7405

>AT239666 WP_098142459.1 NZ_CP094325:22084-22311 [Edwardsiella anguillarum]
METTVFLSNRSQAVRLPKAVALPSDVKRVDIVAVGRTRIITPAGESWDSWFEGEGVSTDFMASREQPKGQEREDF

Nucleotide

• Length: 228 bp

>AT239666 NZ_LS483301:c878212-877952 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA