Detailed information of TA system TA239665

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3588552..3589215
• Replicon: chromosome
• Accession: NZ_CP094324
• Organism: Edwardsiella anguillarum strain Eco2413

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ084_RS16810
• Protein ID: WP_034164690.1
• Coordinates: 3588552..3588968 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ084_RS16815
• Protein ID: WP_012849755.1
• Coordinates: 3588949..3589215 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ084_RS16790 (MQ084_16770)	3584482..3586215	-	1734	WP_034164685.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ084_RS16795 (MQ084_16775)	3586220..3586936	-	717	WP_034164686.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ084_RS16800 (MQ084_16780)	3586964..3587863	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ084_RS16805 (MQ084_16785)	3588015..3588527	+	513	WP_034164689.1	flavodoxin FldB	-
MQ084_RS16810 (MQ084_16790)	3588552..3588968	-	417	WP_034164690.1	protein YgfX	Toxin
MQ084_RS16815 (MQ084_16795)	3588949..3589215	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ084_RS16820 (MQ084_16800)	3589564..3590562	+	999	WP_034164692.1	tRNA-modifying protein YgfZ	-
MQ084_RS16825 (MQ084_16805)	3590604..3591428	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ084_RS16830 (MQ084_16810)	3591585..3592457	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ084_RS16835 (MQ084_16815)	3593066..3593716	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239665 WP_034164690.1 NZ_CP094324:c3588968-3588552 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLTPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRALLDTGDDRA

Nucleotide

• Length: 417 bp

>T239665 NZ_LS483300:c2434555-2434289 [Staphylococcus aureus]
ATGAACAATTACACGGTTAAGATAAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239665 WP_012849755.1 NZ_CP094324:c3589215-3588949 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239665 NZ_LS483300:c2434812-2434555 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAGCATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAATATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8