Detailed information of TA system TA239656

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1901539..1902061
• Replicon: chromosome
• Accession: NZ_CP094324
• Organism: Edwardsiella anguillarum strain Eco2413

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: MQ084_RS09030
• Protein ID: WP_015871319.1
• Coordinates: 1901539..1901820 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: MQ084_RS09035
• Protein ID: WP_015871318.1
• Coordinates: 1901810..1902061 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ084_RS09010 (MQ084_09005)	1896940..1897158	+	219	WP_225865175.1	hypothetical protein	-
MQ084_RS09015 (MQ084_09010)	1897320..1897715	+	396	WP_225865176.1	hypothetical protein	-
MQ084_RS09020 (MQ084_09015)	1897708..1899369	+	1662	WP_049703944.1	terminase	-
MQ084_RS09025 (MQ084_09025)	1899366..1901467	+	2102	Protein_1732	portal protein	-
MQ084_RS09030 (MQ084_09030)	1901539..1901820	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQ084_RS09035 (MQ084_09035)	1901810..1902061	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MQ084_RS09040 (MQ084_09040)	1902349..1902840	+	492	WP_225865179.1	hypothetical protein	-
MQ084_RS09045 (MQ084_09045)	1902827..1903174	+	348	WP_144242832.1	hypothetical protein	-
MQ084_RS09050 (MQ084_09050)	1903546..1905420	+	1875	WP_034165826.1	PhoX family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1868845..1916171	47326

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T239656 WP_015871319.1 NZ_CP094324:c1901820-1901539 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T239656 NZ_LS483297:c4237714-4237541 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT239656 WP_015871318.1 NZ_CP094324:c1902061-1901810 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT239656 NZ_LS483297:c4238038-4237742 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3