Detailed information of TA system TA239654

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3326579..3327242
• Replicon: chromosome
• Accession: NZ_CP094323
• Organism: Edwardsiella anguillarum strain 43472

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ087_RS15115
• Protein ID: WP_283293889.1
• Coordinates: 3326579..3326995 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ087_RS15120
• Protein ID: WP_012849755.1
• Coordinates: 3326976..3327242 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ087_RS15095 (MQ087_15070)	3322509..3324242	-	1734	WP_283293888.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ087_RS15100 (MQ087_15075)	3324247..3324963	-	717	WP_045426732.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ087_RS15105 (MQ087_15080)	3324991..3325890	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ087_RS15110 (MQ087_15085)	3326042..3326554	+	513	WP_034164689.1	flavodoxin FldB	-
MQ087_RS15115 (MQ087_15090)	3326579..3326995	-	417	WP_283293889.1	protein YgfX	Toxin
MQ087_RS15120 (MQ087_15095)	3326976..3327242	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ087_RS15125 (MQ087_15100)	3327591..3328589	+	999	WP_283293890.1	tRNA-modifying protein YgfZ	-
MQ087_RS15130 (MQ087_15105)	3328631..3329455	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ087_RS15135 (MQ087_15110)	3329612..3330484	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ087_RS15140 (MQ087_15115)	3331093..3331743	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239654 WP_283293889.1 NZ_CP094323:c3326995-3326579 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRTLLDTGDDRA

Nucleotide

• Length: 417 bp

>T239654 NZ_LS483297:3687228-3687569 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239654 WP_012849755.1 NZ_CP094323:c3327242-3326976 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239654 NZ_LS483297:3686890-3687207 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8