Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3479933..3480558 | Replicon | chromosome |
Accession | NC_012912 | ||
Organism | Dickeya zeae Ech1591 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | E0SD87 |
Locus tag | DD1591_RS15185 | Protein ID | WP_009114000.1 |
Coordinates | 3480355..3480558 (+) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | C6CQT0 |
Locus tag | DD1591_RS15180 | Protein ID | WP_012770725.1 |
Coordinates | 3479933..3480301 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DD1591_RS15165 | 3475703..3478846 | + | 3144 | WP_012770722.1 | multidrug efflux RND transporter permease subunit | - |
DD1591_RS15170 | 3479014..3479265 | + | 252 | WP_012770723.1 | type B 50S ribosomal protein L31 | - |
DD1591_RS15175 | 3479281..3479424 | + | 144 | WP_012770724.1 | type B 50S ribosomal protein L36 | - |
DD1591_RS15180 | 3479933..3480301 | + | 369 | WP_012770725.1 | Hha toxicity modulator TomB | Antitoxin |
DD1591_RS15185 | 3480355..3480558 | + | 204 | WP_009114000.1 | hemolysin expression modulator Hha | Toxin |
DD1591_RS15190 | 3481137..3481463 | + | 327 | WP_012770726.1 | MGMT family protein | - |
DD1591_RS15195 | 3481493..3482050 | - | 558 | WP_012770727.1 | YbaY family lipoprotein | - |
DD1591_RS15200 | 3482269..3483132 | + | 864 | WP_012770728.1 | acyl-CoA thioesterase II | - |
DD1591_RS15205 | 3483246..3484538 | - | 1293 | WP_012770729.1 | ammonium transporter AmtB | - |
DD1591_RS15210 | 3484582..3484920 | - | 339 | WP_002208627.1 | P-II family nitrogen regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8133.51 Da Isoelectric Point: 8.8500
>T23965 WP_009114000.1 NC_012912:3480355-3480558 [Dickeya chrysanthemi Ech1591]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR
Download Length: 204 bp
>T23965 NC_012912:3480355-3480558 [Dickeya chrysanthemi Ech1591]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGTACGACCATCGATACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCTAACGACGAACTTGAAATGTTCTATTCAGCGGCAGACCATCGTCTGGCTGAATTGACAATGAATAAGC
TCTACGACAAAGTGCCGACTGCTGTGTGGAAATACGTTCGGTAA
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGTACGACCATCGATACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCTAACGACGAACTTGAAATGTTCTATTCAGCGGCAGACCATCGTCTGGCTGAATTGACAATGAATAAGC
TCTACGACAAAGTGCCGACTGCTGTGTGGAAATACGTTCGGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 14165.03 Da Isoelectric Point: 5.1663
>AT23965 WP_012770725.1 NC_012912:3479933-3480301 [Dickeya chrysanthemi Ech1591]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSHGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELQKWKKSKSQLFRMFSEKSICTVVKT
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSHGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELQKWKKSKSQLFRMFSEKSICTVVKT
Download Length: 369 bp
>AT23965 NC_012912:3479933-3480301 [Dickeya chrysanthemi Ech1591]
ATGGATGAGTACACACCCCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGTAGTCATGGTTGGGTGAATGATCCGACCTCTGCGGTCAATCTTCAACTAAACGAACTTATCGAAC
ACATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGCTATGTGAACGGGTTGAAAAATATCTG
GACGATACTTATATTCTTTTCAGCAACTACGGTATAAACGATGCTGAGTTGCAGAAATGGAAAAAATCCAAATCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTTAAAACTTAA
ATGGATGAGTACACACCCCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGTAGTCATGGTTGGGTGAATGATCCGACCTCTGCGGTCAATCTTCAACTAAACGAACTTATCGAAC
ACATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGCTATGTGAACGGGTTGAAAAATATCTG
GACGATACTTATATTCTTTTCAGCAACTACGGTATAAACGATGCTGAGTTGCAGAAATGGAAAAAATCCAAATCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTTAAAACTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1X3RNQ0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5S4UKE6 |