Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3479933..3480558 Replicon chromosome
Accession NC_012912
Organism Dickeya zeae Ech1591

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag DD1591_RS15185 Protein ID WP_009114000.1
Coordinates 3480355..3480558 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6CQT0
Locus tag DD1591_RS15180 Protein ID WP_012770725.1
Coordinates 3479933..3480301 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD1591_RS15165 3475703..3478846 + 3144 WP_012770722.1 multidrug efflux RND transporter permease subunit -
DD1591_RS15170 3479014..3479265 + 252 WP_012770723.1 type B 50S ribosomal protein L31 -
DD1591_RS15175 3479281..3479424 + 144 WP_012770724.1 type B 50S ribosomal protein L36 -
DD1591_RS15180 3479933..3480301 + 369 WP_012770725.1 Hha toxicity modulator TomB Antitoxin
DD1591_RS15185 3480355..3480558 + 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
DD1591_RS15190 3481137..3481463 + 327 WP_012770726.1 MGMT family protein -
DD1591_RS15195 3481493..3482050 - 558 WP_012770727.1 YbaY family lipoprotein -
DD1591_RS15200 3482269..3483132 + 864 WP_012770728.1 acyl-CoA thioesterase II -
DD1591_RS15205 3483246..3484538 - 1293 WP_012770729.1 ammonium transporter AmtB -
DD1591_RS15210 3484582..3484920 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T23965 WP_009114000.1 NC_012912:3480355-3480558 [Dickeya chrysanthemi Ech1591]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T23965 NC_012912:3480355-3480558 [Dickeya chrysanthemi Ech1591]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGTACGACCATCGATACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCTAACGACGAACTTGAAATGTTCTATTCAGCGGCAGACCATCGTCTGGCTGAATTGACAATGAATAAGC
TCTACGACAAAGTGCCGACTGCTGTGTGGAAATACGTTCGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14165.03 Da        Isoelectric Point: 5.1663

>AT23965 WP_012770725.1 NC_012912:3479933-3480301 [Dickeya chrysanthemi Ech1591]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSHGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDAELQKWKKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT23965 NC_012912:3479933-3480301 [Dickeya chrysanthemi Ech1591]
ATGGATGAGTACACACCCCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGTAGTCATGGTTGGGTGAATGATCCGACCTCTGCGGTCAATCTTCAACTAAACGAACTTATCGAAC
ACATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGCTATGTGAACGGGTTGAAAAATATCTG
GACGATACTTATATTCTTTTCAGCAACTACGGTATAAACGATGCTGAGTTGCAGAAATGGAAAAAATCCAAATCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A5S4UKE6

References