Detailed information of TA system TA239642

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3404142..3404805
• Replicon: chromosome
• Accession: NZ_CP094322
• Organism: Edwardsiella anguillarum strain 43664

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ093_RS15650
• Protein ID: WP_283293889.1
• Coordinates: 3404142..3404558 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ093_RS15655
• Protein ID: WP_012849755.1
• Coordinates: 3404539..3404805 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ093_RS15630 (MQ093_15610)	3400072..3401805	-	1734	WP_283293888.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ093_RS15635 (MQ093_15615)	3401810..3402526	-	717	WP_045426732.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ093_RS15640 (MQ093_15620)	3402554..3403453	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ093_RS15645 (MQ093_15625)	3403605..3404117	+	513	WP_034164689.1	flavodoxin FldB	-
MQ093_RS15650 (MQ093_15630)	3404142..3404558	-	417	WP_283293889.1	protein YgfX	Toxin
MQ093_RS15655 (MQ093_15635)	3404539..3404805	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ093_RS15660 (MQ093_15640)	3405154..3406152	+	999	WP_283293890.1	tRNA-modifying protein YgfZ	-
MQ093_RS15665 (MQ093_15645)	3406194..3407018	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ093_RS15670 (MQ093_15650)	3407175..3408047	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ093_RS15675 (MQ093_15655)	3408656..3409306	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239642 WP_283293889.1 NZ_CP094322:c3404558-3404142 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRTLLDTGDDRA

Nucleotide

• Length: 417 bp

>T239642 NZ_LS483297:c631537-631073 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGGCATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239642 WP_012849755.1 NZ_CP094322:c3404805-3404539 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239642 NZ_LS483297:c631872-631537 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8