Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/dnstrm_HI1420(antitoxin)
Location 3083062..3083815 Replicon chromosome
Accession NC_012912
Organism Dickeya zeae Ech1591

Toxin (Protein)


Gene name dhiT Uniprot ID C6CN21
Locus tag DD1591_RS13485 Protein ID WP_012770401.1
Coordinates 3083558..3083815 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID C6CN20
Locus tag DD1591_RS13480 Protein ID WP_012770400.1
Coordinates 3083062..3083550 (-) Length 163 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD1591_RS13455 3078982..3080709 + 1728 WP_012770395.1 hydrogenase large subunit -
DD1591_RS13460 3080720..3081289 + 570 WP_012770396.1 hydrogenase 4 subunit H -
DD1591_RS13465 3081286..3082077 + 792 WP_012770397.1 NADH-quinone oxidoreductase subunit B family protein -
DD1591_RS13470 3082074..3082472 + 399 WP_012770398.1 formate hydrogenlyase maturation HycH family protein -
DD1591_RS13475 3082465..3082962 + 498 WP_012770399.1 hydrogenase maturation peptidase HycI -
DD1591_RS13480 3083062..3083550 - 489 WP_012770400.1 addiction module antitoxin Antitoxin
DD1591_RS13485 3083558..3083815 - 258 WP_012770401.1 DUF4160 domain-containing protein Toxin
DD1591_RS13490 3084329..3084871 + 543 WP_012770402.1 4Fe-4S binding protein -
DD1591_RS13495 3084906..3087056 + 2151 WP_012770403.1 formate dehydrogenase subunit alpha -
DD1591_RS13500 3087326..3088534 + 1209 WP_012770404.1 putative DNA binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(79-157)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9997.60 Da        Isoelectric Point: 8.9654

>T23964 WP_012770401.1 NC_012912:c3083815-3083558 [Dickeya chrysanthemi Ech1591]
MPEIDRLAGLIFHLYFYDDERHHLPHVHVCYGHHELIISIRTGVEIEGYLPNNKRKLALAHIRAHRQQLLSMWERAVVGR
NPGKL

Download         Length: 258 bp

>T23964 NC_012912:c3083815-3083558 [Dickeya chrysanthemi Ech1591]
ATGCCTGAGATTGACAGACTGGCAGGGCTAATTTTCCATTTGTACTTTTACGATGATGAACGGCACCATTTGCCGCATGT
GCATGTTTGTTATGGTCATCATGAACTTATCATCAGTATTCGTACCGGAGTCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGCGCATATCCGGGCCCACCGCCAACAGCTGTTGAGCATGTGGGAACGGGCGGTAGTGGGGAGA
AATCCGGGAAAACTGTGA

Antitoxin


Download         Length: 163 a.a.        Molecular weight: 17978.52 Da        Isoelectric Point: 6.3340

>AT23964 WP_012770400.1 NC_012912:c3083550-3083062 [Dickeya chrysanthemi Ech1591]
MHKIVEVDVIGDFSLRLTYDDGLVCDINLYQYAPDPVFSNASLFIKFGLLPDGSLEWLPDIKISASELRKKGEYVSHTLA
VREQNFADIISRAFYDAVIENRPEILQAALKTAVDKHGNSTVAKEAGAKSRTSLYKSLNKNTHVSLATVVSLAHTVLQLE
EK

Download         Length: 489 bp

>AT23964 NC_012912:c3083550-3083062 [Dickeya chrysanthemi Ech1591]
ATGCATAAAATTGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGACGATGGTCTGGTTTGCGACAT
CAATCTTTATCAATATGCGCCCGACCCGGTGTTTTCGAACGCCAGCCTGTTTATCAAGTTTGGTTTGTTGCCGGACGGTT
CGCTGGAATGGCTGCCTGATATCAAGATTTCCGCATCGGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTGGCG
GTGAGAGAGCAGAATTTTGCCGATATCATCTCCCGCGCCTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
GGCGGCGCTGAAAACCGCAGTAGACAAACATGGCAACAGTACGGTGGCCAAAGAGGCGGGAGCCAAAAGTCGTACCAGTT
TGTATAAGTCATTGAATAAAAATACGCATGTCAGTCTGGCAACGGTAGTGAGTCTGGCCCACACCGTGTTGCAACTGGAA
GAAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S4U6B3

Antitoxin

Source ID Structure
AlphaFold DB C6CN20

References