Detailed information of TA system TA239632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/dnstrm_HI1420(antitoxin)
• Location: 1803754..1804533
• Replicon: chromosome
• Accession: NZ_CP094322
• Organism: Edwardsiella anguillarum strain 43664

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: -
• Locus tag: MQ093_RS08360
• Protein ID: WP_198077053.1
• Coordinates: 1804276..1804533 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: -
• Locus tag: MQ093_RS08355
• Protein ID: WP_283294710.1
• Coordinates: 1803754..1804266 (-)
• Length: 171 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ093_RS08325 (MQ093_08320)	1798879..1800261	+	1383	WP_283294703.1	replicative DNA helicase	-
MQ093_RS08330 (MQ093_08325)	1800289..1800636	+	348	WP_283294704.1	hypothetical protein	-
MQ093_RS08335 (MQ093_08330)	1800746..1801390	+	645	WP_034165085.1	DUF1367 family protein	-
MQ093_RS08340 (MQ093_08335)	1801393..1801692	+	300	WP_283294705.1	DUF1364 family protein	-
MQ093_RS08345 (MQ093_08340)	1801837..1802877	+	1041	WP_283294706.1	hypothetical protein	-
MQ093_RS08350 (MQ093_08345)	1802878..1803387	+	510	WP_071525693.1	hypothetical protein	-
MQ093_RS08355 (MQ093_08350)	1803754..1804266	-	513	WP_283294710.1	DUF2442 domain-containing protein	Antitoxin
MQ093_RS08360 (MQ093_08355)	1804276..1804533	-	258	WP_198077053.1	DUF4160 domain-containing protein	Toxin
MQ093_RS08365 (MQ093_08360)	1804903..1805673	+	771	WP_283294713.1	Rha family transcriptional regulator	-
MQ093_RS08370 (MQ093_08365)	1805795..1806310	+	516	WP_034165088.1	hypothetical protein	-
MQ093_RS08375 (MQ093_08370)	1806399..1807217	+	819	WP_283294714.1	hypothetical protein	-
MQ093_RS08380 (MQ093_08375)	1807451..1807849	+	399	WP_144242831.1	hypothetical protein	-
MQ093_RS08385 (MQ093_08380)	1807966..1808196	+	231	WP_034165090.1	ParD-like family protein	-
MQ093_RS08390 (MQ093_08385)	1808171..1808500	+	330	WP_283294715.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MQ093_RS08395 (MQ093_08390)	1808586..1808933	+	348	WP_283294716.1	phage holin, lambda family	-
MQ093_RS08400 (MQ093_08395)	1808936..1809487	+	552	WP_283294717.1	glycosyl hydrolase 108 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1780956..1826375	45419

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Uncharacterized protein HI1420 (82-161)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9625.29 Da
• Isoelectric Point: 7.4665

>T239632 WP_198077053.1 NZ_CP094322:c1804533-1804276 [Edwardsiella anguillarum]
MPEIDALMGLSFVMYFFDNQTHSLPHVHVKYGEFELVIGIDSGEALEGYLPPKKRKLAESHIKANKTRLLAMWQMAVNGM
HPGKL

Nucleotide

• Length: 258 bp

>T239632 NZ_LS483296:1854189-1854440 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 171 a.a.
• Molecular weight: 18249.67 Da
• Isoelectric Point: 7.3201

>AT239632 WP_283294710.1 NZ_CP094322:c1804266-1803754 [Edwardsiella anguillarum]
MLKIIDVDVVGDHVIEVEFSDGFRGRADLTALFSKPPFSAIADFNRFSLTASGVLNWGDAELSADTVRRMSKGAVVSASS
RSLMPENVEAILRQATWESMSEGRPDILQAALRGYAEQLGHADVIKRAGIASRSSAYKTLSPSTNPSFKSLAKISGAILA
IVRENNAQHG

Nucleotide

• Length: 513 bp

>AT239632 NZ_LS483296:1854437-1854691 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA