239631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1116744..1117336 Replicon chromosome
Accession NZ_CP094322
Organism Edwardsiella anguillarum strain 43664

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag MQ093_RS05085 Protein ID WP_012847872.1
Coordinates 1116744..1116947 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A034T4H2
Locus tag MQ093_RS05090 Protein ID WP_034163649.1
Coordinates 1116968..1117336 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ093_RS05065 (MQ093_05070) 1112026..1113744 - 1719 WP_170228383.1 hypothetical protein -
MQ093_RS05070 (MQ093_05075) 1113741..1114793 - 1053 WP_032082908.1 nucleoid-associated protein -
MQ093_RS05075 (MQ093_05080) 1115179..1115799 + 621 WP_001267012.1 recombinase family protein -
MQ093_RS05080 (MQ093_05085) 1116017..1116244 + 228 WP_024183738.1 DUF2188 domain-containing protein -
MQ093_RS05085 (MQ093_05090) 1116744..1116947 - 204 WP_012847872.1 HHA domain-containing protein Toxin
MQ093_RS05090 (MQ093_05095) 1116968..1117336 - 369 WP_034163649.1 Hha toxicity modulator TomB Antitoxin
MQ093_RS05095 (MQ093_05100) 1117703..1120855 - 3153 WP_034163648.1 efflux RND transporter permease subunit -
MQ093_RS05100 (MQ093_05105) 1120899..1122083 - 1185 WP_034163646.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T239631 WP_012847872.1 NZ_CP094322:c1116947-1116744 [Edwardsiella anguillarum]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T239631 NZ_LS483296:c1144807-1144478 [Escherichia coli]
ATGAATACTTTACCTGCAACAACCCAGCGGGCGGCGAAACCCTGCCTGTCACCCGTGGCTGTCTGGAAAATGCTACTGAC
ACACCTGCTGGAACAACACTATGGTCTGACCCTCAACGACACACCGTTCAGTGAGGAACGAGTTATACAGGAACATATCG
ATGCTGGTATCACGCTGGCTGATACTGTGAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAGACTCCGTATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGACTTGCTAAAAACTAA
CGTGAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14118.85 Da        Isoelectric Point: 6.2108

>AT239631 WP_034163649.1 NZ_CP094322:c1117336-1116968 [Edwardsiella anguillarum]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPRHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT239631 NZ_LS483296:c1145145-1144828 [Escherichia coli]
ATGAGCAATATCACATGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGACT
GCACTACCTGGCTGACCGGGCCAGCATCACCGGTAGATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAAGTCAGCCCCCAACATGCCCACTGCGTCATCCTGTACCAC
AACGGTTTCACCTGTGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A034T4H2

References