Detailed information of TA system TA239630

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3375048..3375711
• Replicon: chromosome
• Accession: NZ_CP094321
• Organism: Edwardsiella anguillarum strain 43473

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MQ094_RS15440
• Protein ID: WP_283293889.1
• Coordinates: 3375048..3375464 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: MQ094_RS15445
• Protein ID: WP_012849755.1
• Coordinates: 3375445..3375711 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ094_RS15420 (MQ094_15395)	3370978..3372711	-	1734	WP_283293888.1	single-stranded-DNA-specific exonuclease RecJ	-
MQ094_RS15425 (MQ094_15400)	3372716..3373432	-	717	WP_045426732.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MQ094_RS15430 (MQ094_15405)	3373460..3374359	-	900	WP_034164688.1	site-specific tyrosine recombinase XerD	-
MQ094_RS15435 (MQ094_15410)	3374511..3375023	+	513	WP_034164689.1	flavodoxin FldB	-
MQ094_RS15440 (MQ094_15415)	3375048..3375464	-	417	WP_283293889.1	protein YgfX	Toxin
MQ094_RS15445 (MQ094_15420)	3375445..3375711	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
MQ094_RS15450 (MQ094_15425)	3376060..3377058	+	999	WP_283293890.1	tRNA-modifying protein YgfZ	-
MQ094_RS15455 (MQ094_15430)	3377100..3377924	-	825	WP_034164693.1	shikimate 5-dehydrogenase	-
MQ094_RS15460 (MQ094_15435)	3378081..3378953	-	873	WP_034164695.1	nucleoside-specific channel-forming protein Tsx	-
MQ094_RS15465 (MQ094_15440)	3379562..3380212	+	651	WP_034164746.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16229.03 Da
• Isoelectric Point: 11.6049

>T239630 WP_283293889.1 NZ_CP094321:c3375464-3375048 [Edwardsiella anguillarum]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSAFWLVLLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGVPCRRRLWLAADSMSREEWGQLRRTLLDTGDDRA

Nucleotide

• Length: 417 bp

>T239630 NZ_LS483296:1019897-1020232 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT239630 WP_012849755.1 NZ_CP094321:c3375711-3375445 [Edwardsiella anguillarum]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT239630 NZ_LS483296:1019649-1019897 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8