Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/dnstrm_HI1420(antitoxin)
Location 1809226..1810005 Replicon chromosome
Accession NZ_CP094321
Organism Edwardsiella anguillarum strain 43473

Toxin (Protein)


Gene name dhiT Uniprot ID -
Locus tag MQ094_RS08395 Protein ID WP_198077053.1
Coordinates 1809748..1810005 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID -
Locus tag MQ094_RS08390 Protein ID WP_283294710.1
Coordinates 1809226..1809738 (-) Length 171 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ094_RS08360 (MQ094_08350) 1804351..1805733 + 1383 WP_283294703.1 replicative DNA helicase -
MQ094_RS08365 (MQ094_08355) 1805761..1806108 + 348 WP_283294704.1 hypothetical protein -
MQ094_RS08370 (MQ094_08360) 1806218..1806862 + 645 WP_034165085.1 DUF1367 family protein -
MQ094_RS08375 (MQ094_08365) 1806865..1807164 + 300 WP_283294705.1 DUF1364 family protein -
MQ094_RS08380 (MQ094_08370) 1807309..1808349 + 1041 WP_283294706.1 hypothetical protein -
MQ094_RS08385 (MQ094_08375) 1808350..1808859 + 510 WP_071525693.1 hypothetical protein -
MQ094_RS08390 (MQ094_08380) 1809226..1809738 - 513 WP_283294710.1 DUF2442 domain-containing protein Antitoxin
MQ094_RS08395 (MQ094_08385) 1809748..1810005 - 258 WP_198077053.1 DUF4160 domain-containing protein Toxin
MQ094_RS08400 (MQ094_08390) 1810375..1811145 + 771 WP_283294713.1 Rha family transcriptional regulator -
MQ094_RS08405 (MQ094_08395) 1811267..1811782 + 516 WP_034165088.1 hypothetical protein -
MQ094_RS08410 (MQ094_08400) 1811871..1812689 + 819 WP_283294714.1 hypothetical protein -
MQ094_RS08415 (MQ094_08405) 1812923..1813321 + 399 WP_144242831.1 hypothetical protein -
MQ094_RS08420 (MQ094_08410) 1813438..1813668 + 231 WP_034165090.1 ParD-like family protein -
MQ094_RS08425 (MQ094_08415) 1813643..1813972 + 330 WP_283294715.1 type II toxin-antitoxin system RelE/ParE family toxin -
MQ094_RS08430 (MQ094_08420) 1814058..1814405 + 348 WP_283294716.1 phage holin, lambda family -
MQ094_RS08435 (MQ094_08425) 1814408..1814959 + 552 WP_283294717.1 glycosyl hydrolase 108 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1786423..1836442 50019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(82-161)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9625.29 Da        Isoelectric Point: 7.4665

>T239620 WP_198077053.1 NZ_CP094321:c1810005-1809748 [Edwardsiella anguillarum]
MPEIDALMGLSFVMYFFDNQTHSLPHVHVKYGEFELVIGIDSGEALEGYLPPKKRKLAESHIKANKTRLLAMWQMAVNGM
HPGKL

Download         Length: 258 bp

>T239620 NZ_LS483258:1527050-1527301 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin


Download         Length: 171 a.a.        Molecular weight: 18249.67 Da        Isoelectric Point: 7.3201

>AT239620 WP_283294710.1 NZ_CP094321:c1809738-1809226 [Edwardsiella anguillarum]
MLKIIDVDVVGDHVIEVEFSDGFRGRADLTALFSKPPFSAIADFNRFSLTASGVLNWGDAELSADTVRRMSKGAVVSASS
RSLMPENVEAILRQATWESMSEGRPDILQAALRGYAEQLGHADVIKRAGIASRSSAYKTLSPSTNPSFKSLAKISGAILA
IVRENNAQHG

Download         Length: 513 bp

>AT239620 NZ_LS483258:1527304-1527705 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References